Nanotoxicology is an emerging branch of toxicology that concerns about the detrimental health issues associated with nanoparticles (NPs) through nanotoxicological studies in biological organisms and the environment [1]. NPs may exert toxicity in several ways, e.g., by interacting with biological fluids or penetrating the central nervous system, leading to cardiac or cerebral dysfunction [2]. NPs may also interact with mediators to result in inflammatory response activation, release ions as breakdown products inducing cellular oxidative stress, or interact with genetic materials and eventually damage DNA, directly or indirectly [2]. These phenomena may lead to increased cancer risks. Of concern, the complex issues of NP-based toxicity may include genotoxicity, molec-ular determinants, physicochemical determinants, exposure routes, biodistribution and biotransformation, and regulations in different sectors.NPs offer new opportunities for industrial, medical, and commercial products. Today, their utilization and global market become exponentially increasing [3]; however, it remains unclear how they affect biological organisms and a poor understanding of their biological effects may lead to unexpected, deleterious health consequences. Although the amount of research assessing the environmental impacts of NPs has increased over past decades, information on the environmental fate, transport, transformation, bioavailability, and relevant toxicity of a variety of nanomaterials is still uncertain. NPs may carry potential risks to human health and the environment through their bulk production, usage, and environmental
In hot rolling processes, the rough rolling process is an essential step for making the medium size bar for final strip products. After rough rolling, the bar usually has longitudinal bending called camber owing to several reasons. Camber should be reduced because it may cause various problems including clogging of finishing mill and strip edge folds. The difficulties to designing a camber-reducing controller are to have a good mathematical model of the rolling process and, consequently, lack of an appropriate validation scheme of the designed control algorithm before applying it to a real system. In this paper, a threedimensional simulator for the rough rolling process using FEM (Finite Element Method) is constructed. An output feedback fuzzy controller that does not require a mathematical model is then designed to reduce camber including the lateral bar movement called side-slipping by tilting the roll. A FEM simulation combined with the proposed controller is carried out to show the effectiveness of this scheme. The results show that camber and side-slipping can be effectively reduced while achieving a reasonable wedge profile.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.