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The purpose of this study was to determine whether combined intervention of treadmill exercise and bone marrow stromal cell (BMSC) transplantation would affect the expression of neurotrophic factors in the sciatic nerve injury (SNI) and neuropathic pain-related cascades in ipsilateral lumbar 4-5 dorsal root ganglion (DRG) during the early or late stage of sciatic nerve regeneration. The rats were randomly divided into the normal control group (CONT, n= 6), sedentary group (SS, n= 24), exercise group (SE, n= 24), BMSC transplantation group (SB, n= 24), BMSC transplantation+exercise group (SBE, n= 24) 1, 2, 3, and 5 weeks after SNI. Single dose of 5× 10⁶ harvested BMSC was injected into the injury area sing by a 30 gauge needle. Treadmill exercise was performed at a speed of 8 m/min for 30 min once a day. Tropomyosin-receptor kinase B, brain-derived neurotrophic factor and ciliary neurotrophic factor were significantly upregulated in the SE and SBE groups at 1- and 2-week postinjury than those in the CONT and SS groups, and SB and SBE groups continuously kept up proinflammatory cytokines until the late stage of regeneration. Nuclear factor kappa-light-chain-enhancer of activated B cells, interleukin and tumor necrosis factor alpha in ipsilateral DRG were progressively decreased by exercise alone application and/or BMSC transplantation at early and late stage of regeneration. Present results provide reliable information that combined intervention of treadmill exercise and BMSC transplantation might be one of the effective treatment strategies for recovering sciatic nerve injury-induced neuropathic pain over time.

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Purpose The purpose of this study is to compare the maximal strength, isokinetic muscle function and anaerobic capacity according to the position of college and professional rugby players. Methods Subjects for this study were 54 athletes and randomly divided into 4 groups: the forwards group in college rugby players (FCRP, n = 10), backs group in college rugby players (BCRP, n = 16), forwards group in professional rugby players (FPRP, n = 16), and backs group in professional rugby players (BPRP, n = 12). Physical fitness was consisted of squat, bench press, bilateral grip strength. Isokinetic knee and trunk muscle functions were measured by Humac Norm device, and anaerobic pedaling power was analyzed by Wingate test. Significant differences between groups were determined with one-way repeated ANOVA. Results As the result of this study, there was no statistically significant difference between the absolute and relative values of the squat and bilateral grip strengths, but bench press was significantly higher in FPRP and BPRP compared to other groups. Isokinetic knee and trunk extensor and flexor muscle strength showed stronger in FPRP and BPRP than those in FCRP and BCRP. In addition, the anaerobic pedaling power was also the highest in FPRP and BPRP. Conclusions Our findings suggest important information that the college rugby players and forwards in professional rugby team should be given scientific training to improve their maximum strength, isokinetic strength and anaerobic power.

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