This paper presents a case study of the setpoint tracking performance of the proportional integral derivative (PID) controller on the Single-Input Single-Output (SISO) and Multi-Input Multi-Output (MIMO) nonlinear digital plants under Gaussian white noise and constant load disturbance for the nonlinear time-delay dynamic system. With the objective of getting a better understanding of the nonlinear discrete-time PID controller, we proposed a case study using two SISO and two MIMO digital plants, and then do the numerical simulations along with the addition of Gaussian white noise and load disturbance to simulate the real environment. In this paper, we compare the results of the system working with and without noise and load disturbance. The study result of this paper shows that on the discrete-time digital nonlinear plant, the PID controller is working well to follow the nonlinear setpoint even under heavy noise and load disturbance. The study compared the performance indexes of the controllers in terms of the maximum error, the Root mean square error (RMSE), the Integral square error (ISE), the Integral absolute error (IAE), and the Integral of time-weighted absolute error (ITAE).

The identification of novel drug-target interactions (DTI) is critical to drug discovery and drug repurposing to address contemporary medical and public health challenges presented by emergent diseases. Historically, computational methods have framed DTI prediction as a binary classification problem (indicating whether or not a drug physically interacts with a given protein target); however, framing the problem instead as a regression-based prediction of the physiochemical binding affinity is more meaningful. With growing databases of experimentally derived drug-target interactions (e.g. Davis, Binding-DB, and Kiba), deep learning-based DTI predictors can be effectively leveraged to achieve state-of-the-art (SOTA) performance. In this work, we formulated a DTI competition as part of the coursework for a senior undergraduate machine learning course and challenged students to generate component DTI models that might surpass SOTA models and effectively combine these component models as part of a meta-model using the Reciprocal Perspective (RP) multi-view learning framework. Following 6 weeks of concerted effort, 28 student-produced component deep-learning DTI models were leveraged in this work to produce a new SOTA RP-DTI model, denoted the Meta Undergraduate Student DTI (MUSDTI) model. Through a series of experiments we demonstrate that (1) RP can considerably improve SOTA DTI prediction, (2) our new double-cold experimental design is more appropriate for emergent DTI challenges, (3) that our novel MUSDTI meta-model outperforms SOTA models, (4) that RP can improve upon individual models as an ensembling method, and finally, (5) RP can be utilized for low computation transfer learning. This work introduces a number of important revelations for the field of DTI prediction and sequence-based, pairwise prediction in general.

PCL is one of important tissue engineering scaffold materials. Besides traditional scaffold fabrication methods, additive manufacturing (AM) techniques have also been used to provide controlled pore size and required geometry. Most AM approaches utilize extrusion or sintering to generate PCL scaffolds, yet few use photo-curing. In this research, photo-curable PCL (PCL-DA) was considered as the scaffold material, which will be photo-polymerized by visible light using a self-developed dynamic masking AM system. In order to improve its strength and hydrophilic character, PEG-diacrylate (PEG-DA) is added in the material system. Three different ratios (6:4, 7:3, 8:2) of PCL-DA to PEG-DA were prepared and characterized by differential scanning calorimetry (DSC), thermomechanical analyzer (TMA), tensile tests, water contact angles, and cell culturing. The results showed that the ratio of 6:4 is the best among the three. A preliminary study of scaffold fabrication was conducted by the AM system to demonstrate the feasibility of adopting photo-curable PCL/PEG-DA for tissue engineering scaffold application.

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