In the experiments, the effect of mineral fertilizers in a dose of N120 P120K120 on phyllophages harmfulness on plants while cultivating Epilobium angustifolium has been studied. The research was carried out on 3 summer Epilobium angustifolium plantings in the conditions of the North-Western region of Russia in the Vologda region. The article notes the positive effect of mineral fertilizers on the productivity of Epilobium angustifolium plants. It has been revealed that the use of fertilizers reduces the damage to plants caused by phyllophages by 13%, and this agrotechnical technique effectiveness is expressed in the yield increase of 3.9%.