[Keywords: ␤ig-h3/TGFBI; extravasation; metastasis; extracellular matrix; colon cancer; integrin ␣ v ␤ 5 ] Supplemental material is available at http://www.genesdev.org.

Ovarian cancer, cervical cancer and endometrial cancer are three relatively common malignant cancers of the female reproductive system. Despite improvements in female genital tract cancer detection and development of new therapeutic approaches, there are still poor prognoses and some do not respond to therapeutic patterns, displaying low survival and high frequency of recurrence. In an era of personalized medicine, novel therapeutic approaches with greater efficacy for these cancers represent an unmet need. One of the actionable signaling pathways is the fibroblast growth factor receptor (FGFR) signaling pathway. Several mutations and alterations in FGF/FGFR family members have been reported in human cancers. FGF/FGFR signaling pathway has become a new target for cancer therapy. This review will summarize the role of FGFR pathway and the genetic alterations of the FGF/FGFR related to female reproductive system cancer. We will describe the available inhibitors of FGFR pathway for potential treatment of female reproductive system cancer. Furthermore, we will discuss FGFR-targeted therapies under clinical development for treatment of female reproductive system cancer.

As a kind of ideal porous absorbents with tunable porosity, large surface areas, and hydrophobicity, conjugated microporous polymers (CMPs) have recently received extensive attention in oil/organic solvent-water separation. However, reports on the application of CMPs in adsorption of erythromycin (ERY) from water are very few. In this work, the adsorption of ERY by three kinds of CMPs was firstly studied. It was observed that all the CMPs extracted ERY quickly from water. The adsorption kinetics of ERY on the three CMPs was well expressed by the pseudo-second-order model, and the adsorption process was found to be mainly controlled by film diffusion. Increasing surface area of the CMPs resulted in greater extent of adsorption. This work may provide fundamental guidance for removal of antibiotics by CMPs.