Abstract-The thermostability and density of water-salt solutions of DNA, irradiated by non thermal coherent millimeter electromagnetic waves with frequency 64.5 GHz have been investigated using the methods of spectrophotometry and densitometry. It is shown that the thermostability of DNA and density of its solutions are increased, depending on time of irradiation. It is expected that under the influence of millimeter electromagnetic radiation the hydration of DNA and ions of Na + that are present in solution decrease. As a result, the physicochemical characteristics of DNA are changed.

Base specificity in the interaction of ethidium with double stranded synthetic RNA homopolymers has been studied by means of spectroscopic (UV-visible absorption and fluorescence), microcalorimetric and dilatometric techniques. The results show a strong base specificity in this interaction, the association constant with poly A:poly U being more than three order of magnitude higher than with poly O:poly C. The interaction is mainly enthalpy driven, the differences in affinity being essentially entropic in origin. These evidences along with the dilatometric data suggest that the observed base specificity may arise from the different extent of water release upon intercalation.

Correlation functions and spectral density of the number of molecules of ligand bound to DNA are calculated theoretically. Kinetics of rates of formation and decomposition of the complex are determined by calculating the dependence of correlation function on concentration of ligand in solution. The analysis of spectral density allows to distinguish "fast" and "slow" adsorption of ligands on macromolecule.

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