Aim. To characterize the influence of psychoemotional stress on a white blood cells number in peripheral blood and clotting parameters. Methods. Lymphocytes, granulocytes, monocytes blood counts and coagulological testing were performed in fifty-one students (26 males and 25 females) during the midyear examinations. Psychological tests were used to reveal stress resistance and predisposition to stress. Results. The higher monocyte counts were found in male group under stress compared to control group. Meanwhile, female group under stress showed higher percentage of granulocytes and lower percentage of lymphocytes compare to control group. Sex differences in stationary speed of clot formation were found in stress and non-stress groups. Both sex groups showed an association of psychoemotional stress and hemostasis parameters, the differences in male group were more marked. Conclusion. The obtained data suggest that psychoemotional stress modulates immune cells and hemostasis parameters in healthy volunteers.