The article presents review data of domestic and foreign scientific researchers on etiopathogenesis and clinical picture of chronic dermatosis - microbial eczema. Among chronic skin diseases, microbial eczema accounts for about 40%. According to the results of epidemiological studies, the incidence of microbial eczema among the inhabitants of the Russian Federation ranges from 6.0 to 15 cases per 1,000 people, which indicates a wide spread of this disease. The urgency of studying ME is conditioned by the persistent tendency to an earlier debut of the disease, weighting of the clinical picture, an increase in the number of relapses, and the spread of the pathological process on the skin. It should be noted that resistance to traditional methods of treatment used in microbial eczema is becoming more and more common. The above factors are the basis for further in-depth study of dermatosis and search for new effective treatment methods.

IMPORTANCE: In 2019, the world faced a serious threat a new coronavirus infection (COVID-19) which entailed severe social and economic losses. Considering the massive spread of COVID-19 in 2020, recently, studying the methods of prevention used to prevent the spread of the disease is considered relevant. RESULTS: We have analyzed scientific publications devoted to the study of prevention in databases, such as Scopus, Web of Science, and CyberLeninka. Antiseptic drugs were of particular interest; thus, this article describes the nonspecific preventive measures with the use of miramistin antiseptic drug. This drug has a wide antimicrobial and antiviral spectrum of action. It has a bactericidal effect on aerobic and anaerobic bacteria, and their association on fungal microflora with significant influences on herpes viruses, human immunodeficiency, hepatitis, and sexually transmitted pathogens. Therefore, for many years, this drug is actively used as a means of prevention. Scientific evidence stating that miramistin can inactivate coronaviruses exists. The obtained data show that miramistin in 0.0001% concentration reduces the infectious activity of human coronavirus almost twice, and miramistin in 0.005% concentration and above completely neutralizes the infectious activity of human coronavirus. It has been proven that miramistin has an immunoadjuvant effect, which leads to increased protective reactions of the skin and enhances skin regeneration due to the activation of cellular and humoral immune responses. CONCLUSION: Miramistin preparation has the following important advantage: it has a selective effect on pathogens and does not have an adverse effect on body tissues.

РЕЗЮМЕ К кожным маркерам рака относят паранеопластические дерматозы, классическим представителем которых является черный акантоз. Представлены данные отечественной и зарубежной литературы об этиологии и патогенезе злокачественного черного акантоза (папиллярно-пигментной дистрофии кожи). В 60-100% случаев черный акантоз сопровождает развитие рака желудка, поджелудочной железы, толстой кишки, легких, матки, молочных желез. Приведена патоморфологическая картина патологического состояния. Представлены сведения о дифференциальном диагнозе: его следует проводить с акантозом, вызванным приемом препаратов, заболеваниями эндокринных желез, врожденными синдромами, болезнью Аддисона, болезнью Дарье. Приведено собственное клиническое наблюдение случая появления злокачественного черного акантоза задолго до того, как был выявлен рак молочной железы у беременной. Описан ход лечения, исход гестации и самого заболевания. Злокачественный черный акантоз является характерным маркером развивающейся злокачественной опухоли в организме. Раннее выявление данного дерматоза врачами любой специализации поможет вовремя установить диагноз злокачественного патологического процесса, своевременно провести комплекс лечебных мероприятий, увеличив шансы пациента на преодоление болезни.Ключевые слова: черный акантоз, злокачественный акантоз, рак и беременность, рак молочных желез.

The article outlines the questions of pathogenesis of acne as well as clinical trial data, which indicate that the skin of patients with acne needs comprehensive care with therapeutic cosmetics. Long term use of medical cosmetics has a positive effect on the course of acne disease. The basis of the study is the use of cosmetics line A “Skinormil” including the patented complex Citobiol lRIS, zinc sulfate and vitamin A. Seventy-four patients with acne of the first, second and third severity were monitored and it was recommended them a comprehensive skin care with medical cosmetics. According to the analysis of the clinical picture, it was concluded that on the background of proper care, there is a positive dynamics in the course of acne.