Purpose:To explore the value of neutrophil to lymphocyte ratio (NLR) and in predicting the prognosis in patients with non-metastatic Colorectal Cancer (CRC).1.2. Methods: 88 surgical CRC patients were retrospectively analyzed. Receiver-operating characteristic (ROC) curve analysis was used to determine the patients' thresholds for NLR and IL-6. Kaplan-Meier curve and Cox regression models were used to assess the prognostic values. Results: ROC analysis was used to calculate cut-off value of NLR. Area Under The Curve (AUC) of NLR was 0.739 (95% CI: 0.634 to 0.844) for Overall Survival (OS), and 0.799 (95% CI: 0.705 to 0.892) for Disease-Free Survival (DFS). The AUC of IL-6 was 0.773 (95% CI: 0.670 to 0.876) for OS, and 0.817 (95% CI: 0.728 to 0.906) for DFS. AUC of NLR+IL-6 was 0.805 (95% CI: 0.710 to 0.899) for OS and 0.853 (95% CI: 0.774 to 0.933) for DFS, which was higher than that of NLR or IL-6 alone for OS and DFS. In addition, high NLR and IL-6 was significantly correlated with tumor differentiation and TNM staging. NLR was positively correlated with . The results of Kaplan-Meier method showed that high NLR+IL-6 was correlated with worse OS and DFS. Conclusion:High NLR+IL-6 acts as a better independent prognostic biomarker of CRC than NLR or IL-6 alone, may be applied in clinical practice to identify high-risk patients.