A search for the Standard Model Higgs boson in proton–proton collisions with the ATLAS detector at the LHC is presented. The datasets used correspond to integrated luminosities of approximately 4.8 fb−1 collected at √s=7 TeV in 2011 and 5.8 fb−1 at √s=8 TeV in 2012. Individual searches in the channels H→ZZ(⁎)→4ℓ, H→γγ and H→WW(⁎)→eνμν in the 8 TeV data are combined with previously published results of searches for H→ZZ(⁎), WW(⁎), bb and τ+τ− in the 7 TeV data and results from improved analyses of the H→ZZ(⁎)→4ℓ and H→γγ channels in the 7 TeV data. Clear evidence for the production of a neutral boson with a measured mass of 126.0±0.4(stat)±0.4(sys) GeV is presented. This observation, which has a significance of 5.9 standard deviations, corresponding to a background fluctuation probability of 1.7×10−9, is compatible with the production and decay of the Standard Model Higgs boson

To investigate how substrate properties influence stem-cell fate, we cultured single human epidermal stem cells on polydimethylsiloxane (PDMS) and polyacrylamide (PAAm) hydrogel surfaces, 0.1 kPa-2.3 MPa in stiffness, with a covalently attached collagen coating. Cell spreading and differentiation were unaffected by polydimethylsiloxane stiffness. However, cells on polyacrylamide of low elastic modulus (0.5 kPa) could not form stable focal adhesions and differentiated as a result of decreased activation of the extracellular-signal-related kinase (ERK)/mitogen-activated protein kinase (MAPK) signalling pathway. The differentiation of human mesenchymal stem cells was also unaffected by PDMS stiffness but regulated by the elastic modulus of PAAm. Dextran penetration measurements indicated that polyacrylamide substrates of low elastic modulus were more porous than stiff substrates, suggesting that the collagen anchoring points would be further apart. We then changed collagen crosslink concentration and used hydrogel-nanoparticle substrates to vary anchoring distance at constant substrate stiffness. Lower collagen anchoring density resulted in increased differentiation. We conclude that stem cells exert a mechanical force on collagen fibres and gauge the feedback to make cell-fate decisions.

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A measurement of the Higgs boson mass is presented based on the combined data samples of the ATLAS and CMS experiments at the CERN LHC in the H → γγ and H → ZZ → 4l decay channels. The results are obtained from a simultaneous fit to the reconstructed invariant mass peaks in the two channels and for the two experiments. The measured masses from the individual channels and the two experiments are found to be consistent among themselves. The combined measured mass of the Higgs boson is m H ¼ 125.09 AE 0.21 ðstatÞ AE 0.11 ðsystÞ GeV. DOI: 10.1103/PhysRevLett.114.191803 PACS numbers: 14.80.Bn, 13.85.Qk The study of the mechanism of electroweak symmetry breaking is one of the principal goals of the CERN LHC program. In the standard model (SM), this symmetry breaking is achieved through the introduction of a complex doublet scalar field, leading to the prediction of the Higgs boson H [1-6], whose mass m H is, however, not predicted by the theory. In 2012, the ATLAS and CMS Collaborations at the LHC announced the discovery of a particle with Higgs-boson-like properties and a mass of about 125 GeV [7][8][9]. The discovery was based primarily on mass peaks observed in the γγ and ZZ → l þ l − l 0þ l 0−(denoted H → ZZ → 4l for simplicity) decay channels, where one or both of the Z bosons can be off shell and where l and l 0 denote an electron or muon. With m H known, all properties of the SM Higgs boson, such as its production cross section and partial decay widths, can be predicted. Increasingly precise measurements [10][11][12][13] have established that all observed properties of the new particle, including its spin, parity, and coupling strengths to SM particles are consistent within the uncertainties with those expected for the SM Higgs boson.The ATLAS and CMS Collaborations have independently measured m H using the samples of proton-proton collision data collected in 2011 and 2012, commonly referred to as LHC Run 1. The analyzed samples correspond to approximately 5 fb −1 of integrated luminosity at ffiffi ffi s p ¼ 7 TeV, and 20 fb −1 at ffiffi ffi s p ¼ 8 TeV, for each experiment. Combined results in the context of the separate experiments, as well as those in the individual channels, are presented in Refs. [12,[14][15][16].This Letter describes a combination of the Run 1 data from the two experiments, leading to improved precision for m H . Besides its intrinsic importance as a fundamental parameter, improved knowledge of m H yields more precise predictions for the other Higgs boson properties. Furthermore, the combined mass measurement provides a first step towards combinations of other quantities, such as the couplings. In the SM, m H is related to the values of the masses of the W boson and top quark through loopinduced effects. Taking into account other measured SM quantities, the comparison of the measurements of the Higgs boson, W boson, and top quark masses can be used to directly test the consistency of the SM [17] and thus to search for evidence of physics beyond the SM.The combination is performed usin...

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