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To the Editor: Corneal alkali burns (CABs) have been a difficult problem in clinical treatment for a long time. In severe cases, blindness occurs; hence, research on the repair mechanism underlying corneal injury is particularly important to identify potential therapeutic targets. Alkaliinduced corneal injuries often trigger aggressive aseptic inflammatory responses, which are key to autoimmune responses. [1] However, Nod-like receptor protein 3 (NLRP3) inflammasomes play an important role in aseptic inflammation. [2] Under stimuli, such as infection or stress, the activated NLRP3 inflammasome not only processes procaspase-1 into mature caspase-1 but also further promotes the maturation and release of interleukin (IL)-1b and IL-18. [3] Taurine (Tau) is widely distributed in ocular structures and is an immune regulator. Tau can maintain the stability of the corneal epithelium and improve the survival rate of corneal epithelial cells through antioxidant effects. [4] The purpose of this study was to investigate the effect of Tau eye drops on CAB and elucidate the mechanism underlying corneal inflammatory responses.

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