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SUMMARYApplications running on leadership platforms are more and more bottlenecked by storage input/output (I/O). In an effort to combat the increasing disparity between I/O throughput and compute capability, we created Adaptable IO System (ADIOS) in 2005. Focusing on putting users first with a service oriented architecture, we combined cutting edge research into new I/O techniques with a design effort to create near optimal I/O methods. As a result, ADIOS provides the highest level of synchronous I/O performance for a number of mission critical applications at various Department of Energy Leadership Computing Facilities. Meanwhile ADIOS is leading the push for next generation techniques including staging and data processing pipelines. In this paper, we describe the startling observations we have made in the last half decade of I/O research and development, and elaborate the lessons we have learned along this journey. We also detail some of the challenges that remain as we look toward the coming Exascale era.

Poly(acrylic acid) (PAA) was polymerized on both termini of Pluronic F87 copolymer using the atom transfer radical polymerization technique to produce a novel block copolymer, PAA-b-F87-b-PAA (F87PAA). The loading of a cationic anticancer drug, doxorubicin (DOX), to F87PAA at different pH values was investigated using isothermal titration calorimetry (ITC), laser light scattering techniques, and UV-vis spectroscopy. At pH of 4.3-7.1, the ITC profile exhibited a significant exothermic peak, which indicated that the drug loading is an enthalpically driven process. At a pH of 4.3, the enthalpy maximum was significantly reduced in the presence of 2 M urea, indicating the existence of hydrogen bonds between the DOX and F87PAA copolymer. At a pH of 7.1, the fraction of bound DOX was close to the stoichiometric proportion of 1:1 to the molar concentration of carboxyl groups in the copolymer, where the drug loading is governed by electrostatic and stacking interactions. The TEM image of the complex indicated the formation of large compound micelles induced by the binding of DOX to the PAA segments.

Although nanoscale spatial heterogeneity of metallic glasses has been demonstrated by extensive experimental and theoretical investigations, the nature of spatial heterogeneity remains poorly known owing to the absence of a structural depiction of the inhomogeneity from experimental insight. Here we report the experimental characterization of the spatial heterogeneity of a metallic glass by utilizing state-of-the-art angstrom-beam electron diffraction and scanning transmission electron microscopy. The subnanoscale electron diffraction reveals that the nanoscale spatial heterogeneity and corresponding density fluctuation have a close correlation with the local structure variation from icosahedronlike to tetragonal crystal-like order. The structural insights of spatial heterogeneity have important implications in understanding the properties and dynamics of metallic glasses.