Nanocarriers capable of circumventing various biological barriers between the site of administration and the therapeutic target hold great potential for cancer treatment. Herein, a redox‐sensitive, hyaluronic acid‐decorated graphene oxide nanosheet (HSG) is developed for tumor cytoplasm‐specific rapid delivery using near‐infrared (NIR) irradiation controlled endo/lysosome disruption and redox‐triggered cytoplasmic drug release. Hyaluronic acid (HA) modification through redox‐sensitive linkages permits HSG a range of advantages over the standard graphene oxide, including high biological stability, enhanced drug‐loading capacity for aromatic molecules, HA receptor‐mediated active tumor targeting, greater NIR absorption and thermal energy translation, and a sharp redox‐dependent response for accelerated cargo release. Results of in vivo and in vitro testing indicate a high loading of doxorubicin (DOX) onto HSG. Selective delivery to HA‐receptor overexpressing tumors is achieved through passive and active targeting with minimized unfavorable interactions with blood components. Cytoplasm‐specific DOX delivery is then achieved through NIR controlled endo/lysosome disruption along with redox‐triggered release of DOX in glutathione rich areas. HSG's specificity is resulted in enhanced cytotoxicity of chemotherapeutics with minimal collateral damage to healthy tissues in a xenograft animal tumor model. HSG is validated the programmed delivery of therapeutic agents in a spatiotemporally controlled manner to overcome multiple biological barriers results in specific and enhanced cancer treatment.

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Quantum resource theories seek to quantify sources of nonclassicality that bestow quantum technologies their operational advantage. Chief among these are studies of quantum correlations and quantum coherence. The former isolates nonclassicality in the correlations between systems, and the latter captures nonclassicality of quantum superpositions within a single physical system. Here, we present a scheme that cyclically interconverts between these resources without loss. The first stage converts coherence present in an input system into correlations with an ancilla. The second stage harnesses these correlations to restore coherence on the input system by measurement of the ancilla. We experimentally demonstrate this interconversion process using linear optics. Our experiment highlights the connection between nonclassicality of correlations and nonclassicality within local quantum systems and provides potential flexibilities in exploiting one resource to perform tasks normally associated with the other.

Hydrogen as an antioxidant gas has been widely used in the medical and biological fields for preventing cancer or treating inflammation. However, controlling the hydrogen concentration is crucial for practical use due to its explosive property when its volume concentration in air reaches the explosive limit (4%). In this work, a polymer-based microcantilever (μ-cantilever) hydrogen sensor located at the end of a fiber tip is proposed to detect the hydrogen concentration in medical and biological applications. The proposed sensor was developed using femtosecond laser-induced two-photon polymerization (TPP) to print the polymer μ-cantilever and magnetron sputtering to coat a palladium (Pd) film on the upper surface of the μ-cantilever. Such a device exhibits a high sensitivity, roughly −2 nm %–1 when the hydrogen concentration rises from 0% to 4.5% (v/v) and a short response time, around 13.5 s at 4% (v/v), making it suitable for medical and environmental applications. In addition to providing an ultracompact optical solution for fast and highly sensitive hydrogen measurement, the polymer μ-cantilever fiber sensor can be used for diverse medical and biological sensing applications by replacing Pd with other functional materials.

We report an experimental implementation of a single-qubit generalized measurement scenario, the positive-operator valued measure (POVM), based on a quantum walk model. The qubit is encoded in a single-photon polarization. The photon performs a quantum walk on an array of optical elements, where the polarization-dependent translation is performed via birefringent beam displacers and a change of the polarization is implemented with the help of wave plates. We implement: (i) trine POVM, i.e., the POVM elements uniformly distributed on an equatorial plane of the Bloch sphere; (ii) symmetric-informationally-complete (SIC) POVM; and (iii) unambiguous discrimination of two nonorthogonal qubit states.