Although antibiotics have been widely used in clinical applications to treat pathogenic infections at present, the problem of drug-resistance associated with abuse of antibiotics is becoming a potential threat to human beings. We report a biohybrid nanomaterial consisting of antibiotics, enzyme, polymers, hyaluronic acid (HA), and mesoporous silica nanoparticles (MSNs), which exhibits efficient in vitro and in vivo antibacterial activity with good biocompatibility and negligible hemolytic side effect. Herein, biocompatible layer-by-layer (LBL) coated MSNs are designed and crafted to release encapsulated antibiotics, e.g., amoxicillin (AMO), upon triggering with hyaluronidase, produced by various pathogenic Staphylococcus aureus (S. aureus). The LBL coating process comprises lysozyme (Lys), HA, and 1,2-ethanediamine (EDA)-modified polyglycerol methacrylate (PGMA). The Lys and cationic polymers provided multivalent interactions between MSN-Lys-HA-PGMA and bacterial membrane and accordingly immobilized the nanoparticles to facilitate the synergistic effect of these antibacterial agents. Loading process was characterized by dynamic light scattering (DLS), transmission electron microscopy (TEM), thermogravimetric analysis (TGA), and X-ray diffraction spectroscopy (XRD). The minimal inhibition concentration (MIC) of MSN-Lys-HA-PGMA treated to antibiotic resistant bacteria is much lower than that of isodose Lys and AMO. Especially, MSN-Lys-HA-PGMA exhibited good inhibition for pathogens in bacteria-infected wounds in vivo. Therefore, this type of new biohybrid nanomaterials showed great potential as novel antibacterial agents.

As eries of rigid nonconjugated polyimide (PI)based thermally activated delayed fluorescence (TADF) polymers were reported for the first time,b ased on a" TADF-Linker-Host" strategy.A mong of which,t he TADF unit contains at ypical TADF luminous core structure,t he "Host" unit exhibits effective conjugation length that endows polyimide with high triplet energy,a nd the "Linker" unit has an aliphatic ring structure to improve solubility and inhibits intramolecular charge transfer effect. All the TADF polymers exhibit high thermal stability (T g > 308.7 8 8C) and refractive index (1.76-1.79). Remarkably,highly-efficient polymer lightemitting diodes (PLEDs) based on the polymers are successfully realized, leading to am aximal external quantum efficiency of 21.0 %a long with lowe fficiency roll-off.S uch outstanding efficiency is amongst the state-of-the-art performance of nonconjugated PLEDs,confirming the effectiveness of structural design strategy,p roviding helpful and valuable guidance on the development of highly-efficient fluorescent polymer materials and PLEDs.

Responsive cross-linked micelles (x-micelles) based on polyurethane with photo-responsive coumarin derivatives and pH-responsive hydrazone groups were synthesized.

A facile organogel was developed to improve drug release and transdermal delivery, and to increase bactericidal activity over 80% in vivo.

Luminophores usually suffer from luminescent quenching when introduced into a polymer backbone or side chain, which leads to the inefficient luminescence or even no luminescence of the polymer. In this work, alicyclic imide rings were found to be capable of balancing the donor–acceptor properties between the rigid spacer and the aggregation-induced emission-active fluorophore in light-emitting polymers. Along with the nonplanar and rigid emitter, the suppressed intramolecular charge-transfer effect and interchain disturbance can efficiently preserve the luminescence characteristics of the active center, resulting in high solid-state photoluminescence quantum yields of up to 89%. The amorphous polyimides exhibit excellent thermal properties, such as high glass transition temperature (T g) values (398 °C) and high thermal decomposition temperature (T d) values (538 °C). As far as we know, these luminescent polymer materials are of excellent heat resistance with the highest luminescence efficiency reported. The results have significant impact for the precise prediction of the optical properties of light-emitting polymers by appropriate monomer design, providing controllable ways for synthesizing high thermal stability polymeric materials with efficient fluorescence properties.