Background: The controlling nutritional status (CONUT) score and the prognostic nutritional index (PNI) score were designed as indicators of patients’ immune-nutritional status. This study aimed to investigate the prognostic impact of the CONUT and PNI scores on long-term recurrent ischemic stroke (RIS) and adverse outcomes for adults with acute ischemic stroke (AIS). Methods: This retrospective study enrolled 991 AIS patients. Multivariable Cox regression models were used to assess the relationships of the malnutritional indices and RIS and major cardiovascular events (MACEs). Results: During a median follow-up at 44 months (IQR 39–49 months), 203 (19.2%) patients had RIS and 261 (26.3%) had MACEs. Compared with normal nutritional status, moderate to severe malnutrition was significantly related to an increased risk of RIS in the CONUT score (adjusted hazard ratio (HR) 3.472, 95% confidence interval (CI) 2.223–5.432, p < 0.001). A higher PNI value tertile (tertile two, adjusted HR 0.295, 95% CI 0.202–0.430; tertile three, adjusted HR 0.445, 95% CI 0.308–0.632, all p < 0.001) was related to a lower risk of RIS. Similar results were found for MACEs. The PNI exhibited nonlinear association with the RIS and both two malnutritional indices improved the model’s discrimination when added to the model with other clinical risk factors. Conclusions: This study demonstrated that the CONUT and PNI are promising, straightforward screening indicators to identify AIS patients with impaired immune-nutritional status at higher risk of long-term RIS and MACEs.

Since the 1990s, there has been much discussion about how concepts are learned and processed. Many researchers believe that the experienced bodily states (i.e., embodied experiences) should be an important factor that affects concepts’ learning and use, and metaphorical mappings between abstract concepts, such as TIME and POWER, and concrete concepts, such as SPATIAL ORIENTATION, STRUCTURED EXPERIENCEs, etc., suggest the abstract-concrete concepts’ connections. In most of the recent literature, we can find common elements (e.g., concrete concepts) shared by different abstract-concrete metaphorical expressions. Therefore, we assumed that mappings might also be found between two abstract concepts that share common elements, though they have no symbolic connections. In the present study, two lexical decision tasks were arranged and the priming effect between TIME and ABSTRACT ACTIONs was used as an index to test our hypothesis. Results showed a robust priming effect when a target verb and its prime belonged to the same duration type (TIME consistent condition). These findings suggest that mapping between concepts was affected by common elements. We propose a dynamic model in which mappings between concepts are influenced by common elements, including symbolic or embodied information. What kind of elements (linguistic or embodied) can be used would depend on how difficult it is for a concept to be learned or accessed.

Purpose: To investigate the effects of quinoa on glucose and lipid metabolism, and the prognosis in people with impaired glucose tolerance.Methods: One hundred and thirty-eight patients diagnosed with impaired glucose tolerance following a glucose tolerance test in Guangzhou Cadre Health Management Center were selected and randomly divided into quinoa intervention and control groups, according to the digital table method. After 1 year of follow-up, the differences in blood glucose, blood lipid, glycosylated hemoglobin and other indicators were compared. The disease prognosis between the two groups was also compared.Results: The 2 h postprandial blood glucose, glycosylated hemoglobin, insulin resistance index, total cholesterol, low-density lipoprotein cholesterol, body mass index, waist circumference, systolic and diastolic blood pressure after intervention in the quinoa group were significantly lower than before intervention. In contrast, high-density lipoprotein cholesterol was higher than before intervention and is statistically significant (p &lt; 0.05). After 1 year of follow-up, the control group’s glycosylated hemoglobin and body mass index are higher than before intervention, and are statistically significant (p &lt; 0.05). The 2 h postprandial blood glucose, glycosylated hemoglobin, insulin resistance index, body mass index, and mean diastolic blood pressure in the quinoa group are statistically significantly lower than in the control group, while high-density lipoprotein cholesterol is higher (p &lt; 0.05). The rate of conversion to diabetes for participants in the quinoa group (7.8%) is statistically significantly lower than in the control group (20.3%) (χ2 = 12.760, p = 0.002). Logistic regression analysis showed that quinoa consumption is a protective factor against delaying the progression of diabetes (p &lt; 0.05).Conclusion: Adding quinoa to staple food intake can reduce postprandial blood glucose, and improve lipid metabolism and insulin resistance, delaying the progression of diabetes in people with impaired glucose tolerance.