Introduction: Mental and behavioral disorders due to the use of substances is a serious public health problem. Deficit in social skills can be considered a risk factor at the beginning or continuity of use. Objective: To evaluate the repertoire of social skills of users of multiple and varied psychoactive substances being treated at the Center for Psychosocial Care in Alcohol and Drugs. Method: The sample was composed of individuals diagnosed with Substance-related Disorder undergoing treatment at the Center for Psychosocial Care for Alcohol and Drug Users of a city in the inner state of of São Paulo. Two investigative instruments were used: sociodemographic characterization and use questionnaire and Social Skills Inventory (IHS). The analysis of sociodemographic data used descriptive statistics and IHS analysis performed by collaborating psychologist through the IHS computerized correction system. Results: A total of 35 users, all male, 42.8% aged 31-35 years, 51.4% single participated in this study. The general average classified them with good repertoire, but individual analysis pointed out 42.8% with repertoire below average. Among deficits, the most affected factors were Factors 1 and 3 related to coping skills and self-assertion with risk and difficulties in conversation and social skills. The number of users with social skill deficits is expressive, especially in coping skills and self-assertion with risk, fact that may be directly related to relapse and abandonment of treatment. Conclusion: It is important to evaluate the repertoire of HS at the beginning of treatment, in order to contribute to the elaboration and implementation of specific training interventions.