This study aims to assess the effects of neuromuscular taping decompression technique (NMT) to modify pain scale in diabetic patients with painful distal symmetrical polyneuropathy and was conducted at Wahidin Sudirohusodo Hospital, Makassar, Indonesia. The study design used a pure experimental design with the pre-test and post-test control group method, where samples were collected using a consecutive sampling technique.30 patients with diabetic painful distal symmetrical polyneuropathy were studied consisting of 15 treatment and 15 control subjects. The treatment group received a specific decompression NMT application over the dorsal and plantar aspect of the foot, bilaterally, 2 times a week for 4 weeks together with vitamin B complex oral supplementation. While a control group only received vitamin B complex. Mann-Whitney test, showed a significant (p <0.05) improved pain scale in the treatment group at day 28, and the average NPRS value of the treatment group was lower than the control. This study has shown a significant effect of NMT decompression technique in reducing pain in Diabetic Painful Distal Symmetrical Polyneuropathy patients. Pain is the major debilitating aspect that negatively influences DM patient mobility and quality of life. The combination of vitamin B1 (100mg), B6 ​​(100mg) and B12 (5000mcg) supplementation and a specific NMT treatment application repeated 8 times over 28 days (5 treatments over 17 days to achieve minimum effective time) to reduce the mean value of NPRS pain scale to 0 (p<0.05). Trial results indicate a possible treatment cycle of 2 NMT1 treatments a week for 4 weeks to significantly reduce pain to mean value 0 in combination with vit. B supplementation. Treatment time was calculated 5-8 min with a tape cost for 50cm approx USD 0,50 per treatment.