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CDIO, namely, the conceive, design, implement and operate, it is the carrier of the life cycle which from the development of product to its running, and it enables students to take the initiative, practical and organic link way to learn project. This paper selects of a main automation professional course "Automatic Control Theory" as the research object, using CDIO educational philosophy to study and explore the teaching and learning of this course, which has formed a teaching mode including active classroom, actively practice, academic research , project research and network learning , after years of teaching practice, it has achieved a good teaching results and reform achievements, and make students improve in practical ability, independent innovation ability, teamwork ability, meanwhile building a broad stage for innovation of talents.