In cellular networks, device-to-device communications can increase the spectrum efficiency, but some conventional schemes only consider uplink or downlink resource allocation. In this paper, we propose the joint uplink and downlink resource allocation scheme which maximizes the system capacity and guarantees the signal-to-noise-and-interference ratio of both cellular users and device-to-device pairs. The optimization problem is formulated as a mixed integer nonlinear problem that is usually NP hard. To achieve the reasonable resource allocation, the optimization problem is divided into two sub-problems including power allocation and channel assignment. It is proved that the objective function of power control is a convex function, in which the optimal transmission power can be obtained. The Hungarian algorithm is developed to achieve joint uplink and downlink channel assignment. The proposed scheme can improve the system capacity performance and increase the spectrum efficiency. Numerical results reveal that the performance of the proposed scheme of jointly uplink and downlink is better than that of the schemes for independent allocation.

Systemic infection with Cryptococcus neoformans , a dangerous and contagious pathogen found throughout the world, frequently results in lethal cryptococcal pneumonia and meningoencephalitis, and no effective treatments and vaccination of cryptococcosis are available. Here, we describe Prm1, a novel regulator of C. neoformans virulence . C. neoformans prm1Δ cells exhibit extreme sensitivity to various environmental stress conditions. Furthermore, prm1Δ cells show deficiencies in the biosynthesis of chitosan and mannoprotein, which in turn result in impairment of cell wall integrity. Treatment of mice with heat-killed prm1Δ cells was found to facilitate the host immunological defence against infection with wild-type C. neoformans . Further investigation demonstrated that prm1Δ cells strongly promote pulmonary production of interferon-γ, leading to activation of macrophage M1 differentiation and inhibition of M2 polarization. Therefore, our findings suggest that C. neoformans Prm1 may be a viable target for the development of anti-cryptococcosis medications and, cells lacking Prm1 represent a promising candidate for a vaccine.

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