Periodontal diseases are chronic infection caused by interactions between microorganisms and the immune system of chronic bacterial infection, environmental, behavioral, and/or genetic factors [1]. Pregnant condition, as an environmental factor, increases the response of gingival tissue to microbial plaque, which is prone to causing gingivitis during pregnancy. It has been reported that the prevalence of gingivitis in pregnancy is 36-100% [2,3]. Gingivitis in pregnancy may be healed or alleviated after delivery [4]. The increase in hormone activity during pregnancy aggregates the existed gingival chronic inflammation, so the gums easily bleed, swell, and even form tumor-like changes that affect the chewing, digestion and absorption of pregnant women [5,6]. Study by Offenbacher, et al. has shown that pregnant patients with periodontitis have a high degree of inflam-CLiniCaL ReSeaRCH aRtiCLe
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