Herein, we discuss more than 50 cyclin-dependent kinase (CDK) inhibitors that have been approved or have undergone clinical trials and their therapeutic application in multiple cancers. This review discusses the design strategies, structure–activity relationships, and efficacy performances of these selective or nonselective CDK inhibitors. The theoretical basis of early broad-spectrum CDK inhibitors is similar to the scope of chemotherapy, but because their toxicity is greater than the benefit, there is no clinical therapeutic window. The notion that selective CDK inhibitors have a safer therapeutic potential than pan-CDK inhibitors has been widely recognized during the research process. Four CDK4/6 inhibitors have been approved for the treatment of breast cancer or for prophylactic administration during chemotherapy to protect bone marrow and immune system function. Furthermore, the emerging strategies in the field of CDK inhibitors are summarized briefly, and CDKs continue to be widely pursued as emerging anticancer drug targets for drug discovery.

No abstract

In order to protect the products in the circulation process, cushioning packaging materials are used for the general packaging design, that is, to determine the process of circulation of products, product features and the vibration transmission characteristics of package materials and so on. This test system obtains the vibration transmission curves by the test of vibration transmission characteristics of packaging materials. This provides a reliable data basis for anti-vibration design so that the properties of cushioning materials can be played well and protects the products while reducing packaging cost, thus products can be competitive in a good position in the markets.

No abstract

In this paper, a method is proposed for the cushioning package design of notebook computers with total corrugated cardboard through the market survey currently. A way of the evaluation for cushion package design for notebook computers is mentioned as simulation technology. A simple simulation model of the cushioning package of notebook computers has been made drop analysis and stress analysis by use of simulation software ANSYS. It has verified the feasibility and practicality of the method of whole corrugated cardboard cushioning package design. It has pointed out the direction of the development of the cushioning package design for notebook computers.