A recent epigenetic measure of aging has developed based on human cortex tissue. This cortical clock (CC) dramatically outperformed extant blood-based epigenetic clocks in predicting brain age and neurological degeneration. Unfortunately, measures that require brain tissue are of limited utility to investigators striving to identify everyday risk factors for dementia. The present study investigated the utility of using the CpG sites included in the CC to formulate a peripheral blood-based cortical measure of brain age (CC-Bd). To establish the utility of CC-Bd, we used growth curves with individually varying time points and longitudinal data from a sample of 694 aging African Americans. We examined whether three risk factors that have been linked to cognitive decline—loneliness, depression, and BDNFm—predicted CC-Bd after controlling for several factors, including three new-generation epigenetic clocks. Our findings showed that two clocks—DunedinPACE and PoAm—predicted CC-BD, but that increases in loneliness and BDNFm continued to be robust predictors of accelerated CC-Bd even after taking these effects into account. This suggests that CC-Bd is assessing something more than the pan-tissue epigenetic clocks but that, at least in part, brain health is also associated with the general aging of the organism.

Objective: The association between childhood adversity and adulthood health is well established, but few studies have examined potential effects of childhood adversity on partner health in couples. This study examined the long-term health impact of childhood adversity on individuals as well as their significant others. Method: The participants were 163 distinguishable dyads from the Family and Community Health Study. Health outcomes included both self-reported chronic illness and a messenger RNA index of accelerated aging. The actor-partner interdependence model with structural equation methods was used to test the hypothesis. Results: Replicating prior research, childhood adversity was associated with more chronic illness and an accelerated speed of aging. Further, participants’ health in adulthood was affected by both own and partner experiences of childhood adversity. There were no gender differences. Conclusion: Our findings replicate and extend prior research on the long-term impact of exposure to childhood adversity, suggesting that adverse childhood experiences are also harmful to romantic partners. Further studies are required to examine potential mechanisms.