Climate variability and change is a major driver of infectious diseases around the world. This study sought to investigate the role of climate variability on the emergence of malaria in the North West region of Cameroon. Both biophysical and socio-economic data were collected for this study. Biophysical data, mainly secondary, was collected from meteorological stations (rainfall and temperature data) and hospitals (malaria morbidity and mortality statistics) in the study area. Socio-economic data were collected from primary sources, mainly, survey of households and hospitals, using semi-structured questionnaires. A total of 164 questionnaires were distributed amongst medical personnel and the general public (aged 18-70 years). Data obtained were analyzed using descriptive and inferential statistics. Findings revealed that patterns of fluctuation in climate parameters did not have a perfect match with rates of prevalence of malaria. However, some relatively significant correlation was found to exist between certain aspects of climate and rates of prevalence of malaria. It was noted that other drivers are involved in influencing rates of prevalence of malaria besides climate variability and change. Amongst the impacts of malaria prevalence on the population were high rates of morbidity and mortality. The population employed treated mosquito bed nets as the main coping strategy for fighting against malaria. The study recommends that the health sector should incorporate the phenomena of climate variability and change into its policy framework, and more research should be conducted to assess other drivers of malaria prevalence in north western Cameroon.