The FGFR gene rearrangements, such as FGFR1, FGFR2 and FGFR3, have been found in a variety of cancers, including cholangiocarcinoma, bladder cancer, breast cancer, thyroid cancer, head and neck cancer, lung cancer, and liver cancer.1,2 FGFR1/2/3 fusions were detected in 3.5% of patients with squamous cell lung cancer and 1.3% of patients with non-small cell lung cancers (NSCLC). 3 Here, we describe a novel FGFR1 rearrangement (SHANK2-FGFR1) in a intestinal adenocarcinoma patient.

Cerebellar cryptococcoma is a rare clinical condition and is seldom considered as a differential diagnosis for cerebellar masses. Here, we present a case of cerebellar cryptococcoma mimicking abscess in an immunocompetent patient and summarize recent related studies in brief. The incidence of cerebellar cryptococcoma in immunocompetent patients has increased to up to 5 cases reported since 2007, but no case was reported before. A 68-year-old nonimmunocompromised woman complained of progressive occipital headache, vomiting, fatigue, and slight dizziness. Magnetic resonance imaging revealed an irregular lobulated thick-walled cystic lesion present within the cerebellum. The patient underwent a right suboccipital craniotomy for gross total resection of the lesion. The cryptococcoma was diagnosed subsequently by pathologic examination. A full course of antifungal treatment was administrated and the patient had full recovery with no lesion recurrence. Although it is a rare clinical condition in immunocompetent patients, cerebellar cryptococcoma needs to be taken into consideration in the differential diagnosis of cystic lesions of the cerebellum. Practically, microsurgical excision not only solves the mass-occupying effect, but also obtains histologic examination for confirmatory diagnosis. Microsurgical excision-combined antifungal treatment led to a good result in the present case.Key Word: antifungal treatment, cystic brain tumor, cerebellum, cryptococcoma, microsurgical excision, tuberculous abscess (Neurosurg Q 2012;22:266-270) C ryptococcosis is thought to be the most prevalent fungal infection involving the central nervous system (CNS). 1,2 The most frequent manifestations of CNS cryptococcal infections are cryptococcal meningitis or meningoencephalitis. 1,3,4 It is much more common for cryptococcal infections of the CNS to occur in patients with human immunodeficiency virus (HIV) infection and other immunosuppressed conditions. 4,5 Rarely, solitary cerebral lesions attributed to cryptococcosis are considered in the differential diagnosis of abscess or cystic tumors, and they are much more uncommon to be localized in the cerebellum in immunocompetent patients. 3,6 We present a case of a solitary cerebellar cryptococcoma mimicking an abscess or a cystic neoplasm, treated successfully by microsurgery together with antifungal therapy, suggesting the importance of early recognition of this disease in immunocompetent patients. CASE REPORTOur patient is a 68-year-old woman who presented with progressive occipital headache, vomiting, fatigue, and slight dizziness for 2 weeks. Her medical history showed that she was healthy and did not have any long-term medication or drug abuse. Before being treated by our hospital, she took some antibiotics to prevent bacterial infection, as she was diagnosed with a common cold at a local hospital. On the day of admission, her general physical examination and vital signs including body temperature were normal. On neurological examination, she was conscious, oriented, and her speec...

Background: Fatigue is prevalent in breast cancer patients undergoing postoperative chemotherapy, which seriously affects physical and mental health. The present study aimed to investigate the relevance of fatigue, the self-efficacy of managing chronic disease (SEMCD), and the dual-mode of self-control (DMSC) in patients. Methods: Three hundred and seventy six breast cancer patients undergoing postoperative chemotherapy participated in this cross-sectional study. The General Information Questionnaire, Fatigue Scale-14 (FS-14), SEMCD-Scale (SEMCD-S), and DMSC-Scale (DMSC-S) were utilized to survey. Pearson correlation analysis and structural equation modeling were used for the statistical analysis of the correlation between the variables and mediating effects. Results: A total of 372 valid questionnaires (98.94%) were returned. The total fatigue score of FS-14 was (10.84 ± 1.80), the SEMCD-S score (30.05 ± 15.18), and the DMSC-Scale score (73.35 ± 9.49). Furthermore, physical fatigue was negatively correlated with the SEMCD-S and problem solving (r = −0.764 ~ −0.680, P < 0.01). Mental fatigue correlated positively with poor delay of gratification (r = 0.134, P < 0.05), and the SEMCD-S was also negatively correlated with the impulsivity, distractibility, and poor delay of gratification dimensions (r =-0.229~-0.130, P < 0.05). SEMCD correlated positively with problem-solving and future time perspective (r = 0.695~0.790, P < 0.001). In addition, SEMCD partially mediated the effect between the DMSC and fatigue (β = −0.335, P < 0.01), with the mediating effect accounting for 51.25%. Conclusion: Through SEMCD measure, it was found that DMSC indirectly influences fatigue levels in breast cancer patients undergoing postoperative chemotherapy.