The optical vortex (OV) beams characterized by orbital angular momentum (OAM) possess ubiquitous applications in optical communication and nanoparticle manipulation. Particularly, the vortex vector beams are important in classical physics and quantum sciences. Here, based on an all-dielectric transmission metasurface platform, we demonstrate a spin-multiplexed metadevice combining propagation phase and Pancharatnam–Berry (PB) phase. By utilizing a phase-only modulation method, the metadevice can generate spin-dependent and multidimensional focused optical vortex (FOV) under the orthogonally circularly polarized incident light, and it can successfully realize the multiplexed of the above-mentioned FOVs for linearly polarized light. Meanwhile, the superposition of multiple OAM states can also produce vector vortex beams with different modes. Additionally, the evolution process of the electric field intensity profile is presented after the resultant vector vortex beams through a horizontal linear polarization. This work paves an innovative way for generating structured beams, and it provides promising opportunities for advanced applications in optical data storage, optical micromanipulation, and data communication.

Metasurfaces, employed to simultaneously generate nanoprinting and holographic images, have been extensively explored recently. Among them, multi-wavelength multiplexing in a single metasurface is often accompanied by dispersion and crosstalk, which hinder the display of multicolor patterns. Here, we propose an efficient phase method to decouple the wavelength and realize a three-channel display operating at different wavelengths. Holographic images appear in the far field with the illumination of two different circularly polarized lights while a nanoprinting image is reconstructed by inserting an orthogonal optical path with the illumination of linear polarization light. The proposed metasurface is only composed of four types of unit cells, which significantly decreases the complexity of fabrication and improves the information capacity. Benefiting from its different decoding strategies and capability of multi-wavelength control, this approach may develop broad applications in information encryption, security, and color display.

Annexin A2 ( ANXA2 ) encodes an oncoprotein whose expression has been found to correlate with poorer overall survival (OS) of pancreatic adenocarcinoma (PAAD) patients. Although peptides are available for targeting ANXA2 , none of these were initially selected to target this protein specifically. Here, we took ANXA2 as a molecular target for PAAD and employed the phage display technique to screen for a new ANXA2 ‐targeted peptide. The resultant heptapeptide, YW7, was firstly labeled with fluorescein isothiocyanate (FITC) to evaluate its selectivity in cellular uptake, and further with the near‐infrared fluorescent (NIRF) dye Cy7 to assess in vivo distribution in a mouse model bearing PANC‐1 human pancreatic cancer xenografic tumors. We found that both FITC‐YW7 and Cy7‐YW7 probes showed significantly higher uptake in PANC‐1 cells compared to the HPDE6‐C7 pancreatic epithelium cells. Mice intravenously injected with Cy7‐YW7 showed higher tumor‐to‐background ratios (TBRs) (~ 2.7‐fold) in tumor tissues compared to those injected with Cy7 alone. Our study suggested that YW7 is a novel peptide targeting ANXA2 and Cy7‐YW7 is an NIRF probe potentially useful for the early detection of PAAD.

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