Background The intercellular adhesion molecule‐1 (ICAM‐1)/leukocyte function associated antigen‐1 (LFA‐1) adhesion system regulates leukocyte interactions, migration, and adhesion, and appears to play an important role in atherosclerosis and thrombosis. Therefore, single nucleotide polymorphisms (SNPs) of the ICAM‐1 gene may strongly influence the expression and biological activity of ICAM‐1 and play a potentially important role in the pathogenesis of ischemic stroke. In the current meta‐analysis, we investigated the relationship between the ICAM‐1 gene K469E SNP and the risk of ischemic stroke. Methods Two investigators independently searched PubMed, Web of Science, Google Scholar, WANFANG, China National Knowledge Infrastructure (CNKI) and J‐STAGE for studies published from January 2000 to February 2019 without language restriction. The association of K469E polymorphism and ischemic stroke in three genetic models (allelic, recessive, and dominant) were evaluated using Pooled odds ratios (ORs) with 95% confidence intervals (CIs). Results Our study included 20 studies from four continents and four different countries, including 3,137 cases and 15,382 controls. Meta‐analysis results did not show a significant association between K469E polymorphism of ICAM‐1 gene and ischemic stroke when assuming allelic model (OR: 1.12; 95% CI: 0.8 to 1.55; p = 0.51; I 2 = 93%) or recessive model (OR: 1.28; 95% CI: 0.89 to 1.84; p = 0.18; I 2 = 82%) or dominant model (OR: 1.20; 95% CI: 0.92 to 1.56; p = 0.17; I 2 = 85%). However, in all three genetic models, subgroup analysis revealed that the K469E polymorphism of the ICAM‐1 gene is associated with ischemic stroke in the Caucasian population. Conclusion K469E polymorphism of ICAM‐1 gene might be a risk factor for ischemic stroke in Caucasians, which suggested that K469E polymorphism might help in early identification of those at risk and help in primary prevention of ischemic stroke.

Using observations from the Heihe Watershed Allied Telemetry Experimental Research (HiWATER) datasets, the effect of radiative forcing on the development of the stable boundary layer (SBL) and diurnal temperature range (DTR) during summer over the central Heihe River Basin is investigated in this paper. Using a radiative temperature scale based on net longwave radiation (LW net24), the DTR and the strength of SBL (δT S) are scaled, and the cycle and the year-to-year variability before and after scaling are analyzed. The results show that both DTR from air and surface temperatures have a significant correlation with LW net24 , and their correlation coefficients are different over different underlying surfaces. The cycle of DTR from 5-m air temperature is similar with that of LW net24. There is only a diurnal cycle in terms of 5-m air temperature after scaling. Both the trends of the scaled DTR (DTR sc) and the scaled strength of SBL (δT Ssc) increase with the growth time of the stable boundary layer (SBL) (τ S). The period of τ S is similar with that of DTR sc. τ S is longer at the oasis site than at the Gobi site, which is related to the oasis effect. In addition, the greater the friction velocity, the smaller the DTR sc and δT Ssc. The wind shear enables heat to disperse during SBL.