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Background: With the increase in the elderly and advances in surgical techniques of pancreatectomy, the number of surgeries performed for pancreatic ductal adenocarcinoma (PDAC) in this age group has been rising. In this study, we aimed to evaluate the technical and oncological safety of pancreatectomy for the elderly aged ≥75 years with pancreatic cancer by retrospectively comparing their short- and long-term outcomes with those of non-elderly aged <75 years.Methods: Data were collected from 117 patients who underwent pancreatectomy for PDAC in our department. The indication for surgery in terms of patient characteristics was considered according to each patient’s American Society of Anesthesiologists physical status (ASA-PS) and Eastern Cooperative Oncology Group Performance Status Scale. Data of the elderly (n=32) were compared with those of the non-elderly (n=85) and comprised patient background, surgical factors, postoperative course, histopathological factors, and prognostic factors. Additionally, prognostic nutritional index (PNI) values preoperatively and at 1 and 6 months postoperatively were compared between the two groups.Results: In terms of patient background, ASA-PS and comorbidities were worse in the elderly. However, there were no significant differences in surgical factors, postoperative courses, and histopathological factors between the two groups. There were no differences in lengths of recurrence-free survival and overall survival (non-elderly vs. elderly: median 9 vs. 8 months, p=0.725, and median 25 vs. 19 months, p=0.395, respectively) between the two groups. Furthermore, no significant differences were found in PNI preoperatively to 6 months after the surgery.Conclusion: With careful patient screening, the technical and oncological safety of pancreatectomy for the elderly appears to be comparable to that for the non-elderly.