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incidence compared with patients without cancer. VTE is reported to be the second most frequent cause of death in patients with cancer undergoing chemotherapy. 4 Furthermore, VTE in patients with cancer could develop through not only hypercoagulability with cancer, but also treatmentrelated factors including new molecular target therapeutic agents, which have further increased the risk for development of VTE in the current era. 5 A recent study reported Cancer is a progressive disease with a high mortality rate despite intensive treatment, but many cancer patients are surviving longer because of progress in early diagnosis and treatment. 1,2 Thus, complications during the treatment course of cancer are becoming more clinically relevant. Cancer is a strong risk factor for the development of venous thromboembolism (VTE), and patients with cancer are reported to have a 7-fold higher

Endoprosthetic or biological reconstructions as limb salvage provided good functional outcome in skeletally immature children with a malignant bone tumor of the distal aspect of the femur despite a high rate of revisions and limb-lengthening procedures.

The current study indicates that the number of osteosarcoma patients over 60 years is increasing. The number of cases with secondary osteosarcoma over 60 years is relatively small in Japan, with no patients having osteosarcomas related to Paget's disease. Although there is a predilection for axial localization, surgical treatment has a significant impact on patient's prognosis.

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