Different numbers of self-gravitating particles (in different types of periodic motion) are most likely to generate very different shapes of gravitational waves, some of which, however, can be accidentally almost the same. One such example is a binary and three-body system for Lagrange's solution. To track the evolution of these similar wave forms, we define a chirp mass to the triple system. Thereby, we show that the quadrupole wave forms cannot distinguish the sources. It is suggested that wave forms with higher lth multipoles will be important for classification of them (with a conjecture of l

SUMMARYHelicobacter pylori, a common pathogen that causes chronic gastritis and cancer, has evolved to establish persistent infections in the human stomach. Epidemiological evidence suggests that H. pylori with both highly active vacuolating cytotoxin A (VacA) and cytotoxin-associated gene A (CagA), the major virulence factors, has an advantage in adapting to the host environment. However, the mechanistic relationship between VacA and CagA remains obscure. Here, we report that CagA interferes with eukaryotic endocytosis, as revealed by genome-wide screening in yeast. Moreover, CagA suppresses pinocytic endocytosis and the cytotoxicity of VacA in gastric epithelial cells without affecting clathrin-dependent endocytosis. Our data suggest that H. pylori secretes VacA to attack distant host cells while injecting CagA into the gastric epithelial cells to which the bacteria are directly attached, thereby protecting these attached host cells from the cytotoxicity of VacA and creating a local ecological niche. This mechanism might allow H. pylori to balance damage to one population of host cells with the preservation of another, allowing for persistent infection.

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