Single-handed α-amino acid derivatives were generated from achiral precursors without an external chiral source. Conjugate addition of phenethylamine to an achiral aroyl acrylamide under homogeneous conditions gave the α-amino amides in quantitative yields, which crystallized as a conglomerate of a P2 crystal system. Dynamic preferential crystallization or attrition-enhanced deracemization resulted in the formation of enantiomorphic crystals of 99 % ee.

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A New Class of C 2 Chiral Photodimer Ligands for Catalytic Enantioselective Diethylzinc Addition to Arylaldehydes. -(UEDA, Y.; YAGISHITA, F.; ISHIKAWA, H.; KAJI, Y.; BABA, N.; KASASHIMA, Y.; MINO, T.; SAKAMOTO*, M.; Tetrahedron 71 (2015) 36, 6254-6258, http://dx.