Cell therapy with adipose tissue-derived stem cells (ASCs) is expected to be a candidate for the treatment of fulminant hepatic failure (FHF), which is caused by excessive immune responses. In order to evaluate the therapeutic effects of ASCs on FHF, the in vitro and in vivo immunomodulatory effects of ASCs were examined in detail in the mouse model. The in vitro effects of ASCs were examined by assessing their influence on the proliferation of lymphomononuclear cells (LMCs) stimulated with three kinds of mitogens: phorbol 12-myristate 13-acetate (PMA) plus ionomycin, concanavalin A (ConA), and lipopolysaccharide (LPS). The proliferation of LMCs was efficiently suppressed in a dose-dependent manner by ASCs in the cases of PMA plus ionomycin stimulation and ConA stimulation, but not in the case of LPS stimulation. The in vivo effects of transplanted ASCs were examined in the murine FHF model induced by ConA administration. The ALT levels and histological inflammatory changes in the ConA-administered mice were apparently relieved by the transplantation of ASCs. The analysis of mRNA expression patterns in the livers indicated that the expressions of the cytokines such as , and the cell surface markers such as Cd3γ, Cd4, Cd8α, Cd11b, and Cd11c were downregulated in the ASC-transplanted mice. The immunomodulatory and therapeutic effects of ASCs were confirmed in the mouse model both in vitro and in vivo. These suggest that the cell therapy with ASCs is beneficial for the treatment of FHF.

We examine an exact solution which represents a charged black hole in a Kaluza-Klein universe in the five-dimensional Einstein-Maxwell theory. The spacetime approaches to the five-dimensional Kasner solution that describes expanding three dimensions and shrinking an extra dimension in the far region. The metric is continuous but not smooth at the black hole horizon. There appears a mild curvature singularity that a free-fall observer can traverse the horizon. The horizon is a squashed three-sphere with a constant size, and the metric is approximately static near the horizon.

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3 名城大学 理工学部環境創造学科（〒468-8502 名古屋市天白区塩釜口1-501） 土壌気相中の物質移動に関する物性値は，屈曲度を考慮した分子拡散係数とKnudsen拡散係数および分 散長となる．日比らは，以前の研究でカラム実験結果よりこれらの物性値を求める手法を開発した．本研 究では，カラム実験より得られた物性値が妥当な値であるか確認するために二次元土槽実験と数値解析を 行った．二次元土槽実験では，物性値が得られている乾燥した豊浦砂または豊浦砂とベントナイトの混合 土と，酸素と窒素を成分調整した混合ガスで満たされた土槽に二酸化炭素を注入した．二次元土槽実験に 関する数値解析は，Dusty Gas Model を特性曲線型有限要素法で定式化した手法と，以前の研究でカラム 実験より得られた物性値を用いて行われた．その結果，カラム実験で得られたこれらのパラメーターが適 切な値であることが分かった．