Pathological conditions such as epilepsy cause misregulation of adult neural stem/progenitor populations in the adult hippocampus in mice, and the resulting abnormal neurogenesis leads to impairment in learning and memory. However, how animals cope with abnormal neurogenesis remains unknown. Here we show that microglia in the mouse hippocampus attenuate convulsive seizure-mediated aberrant neurogenesis through the activation of Toll-like receptor 9 (TLR9), an innate immune sensor known to recognize microbial DNA and trigger inflammatory responses. We found that microglia sense self-DNA from degenerating neurons following seizure, and secrete tumour necrosis factor-a, resulting in attenuation of aberrant neurogenesis. Furthermore, TLR9 deficiency exacerbated seizure-induced cognitive decline and recurrent seizure severity. Our findings thus suggest the existence of bidirectional communication between the innate immune and nervous systems for the maintenance of adult brain integrity.

平成 30 年 7 月豪雨の土砂災害と水害による建物被害の特性に関する研究 -広島県三原市の罹災証明書データを用いた分析-Study on the characteristics of building damages caused by sediment disaster and flood disaster of the heavy rain event of July 2018 -Analysis using disaster victim certificate data of Mihara City in Hiroshima Prefecture -

No abstract

Recently, the wild boar damage has been increasingly serious in "Bingo Sports Park". To take effective measures, it is necessary to understand where the damage tends to be caused. This study aims at identifying the main factors on wild boar damage by using logistic regression analysis and creating the estimation map of wild boar damage based on the result. Results shows that the wild boars tend to cause more damage in areas with more natural land cover and closer to roads and valleys.