The age of the population is shifting toward the elderly range, which may lead to an increased risk of mild cognitive impairment (MCI). The aims of this study are to evaluate the cognitive function in elderly people using the Montreal Cognitive Assessment (MoCA), to identify the relationship between cognitive function and different characteristics, and to evaluate the efficacy of the intervention after six months of cognitive training. In this study, we included 2886 subjects aged ≧60 years in the baseline survey, and 140 subjects with MCI who participated in the baseline survey were randomly divided into an intervention group (N = 70) and a control group (N = 70). The control group was not provided any intervention measures, and the intervention group was administered cognitive training. The education level, monthly income, sleep time, exercise time, reading times, and time spent engaging in community activities and performing housework were positively correlated with MoCA scores, but age was negatively correlated with MoCA scores. The total MoCA score of the intervention group increased from 19.77 ± 2.24 points to 21.09 ± 2.20 points after six months of cognitive training, but the score of the control group decreased from 20.41 ± 2.10 points to 19.17 ± 2.57 points. The two-way repeated-measures ANOVA revealed a very significant effect of the interaction between time and cognitive training on the total MoCA score. Seventeen participants in the intervention group improved to normal levels, and no participants progressed to dementia after six months of cognitive training. Thus, the efficacy of the intervention was statistically significant. Our study concludes that older age is associated with a cognitive decline. Factors that are more likely to protect against cognitive decline included a higher education level and monthly income, sufficient sleep time, regular physical exercise and reading, frequently engaging in community activities, and continuing to perform housework. Moreover, the cognitive training intervention is effective and may help to decrease the deterioration of cognitive function in patients with MCI, and the interaction between intervention time and cognitive training significantly improves cognitive function.

BackgroundThe aim of this study was to determine the association between the incidence of road traffic accidents, psychological characteristics, and genotype in bus drivers in a Chinese population.Material/MethodsBus drivers who had been involved in road traffic accidents (n=106) (the study group), and bus drivers with no history of road traffic accidents (n=106) (the control group) completed demographic questionnaires, the Eysenck Personality Questionnaire (EPQ) and the Type-A behavior pattern (TABP) evaluation. Serum 5-hydroxytryptamine (5-HT) (serotonin), and 5-hydroxytryptophan (5-HTP) levels were measured by high-performance liquid chromatography-fluorescent detection (HPLC-FLD). Serotonin transporter promoter-linked polymorphism region (5-HTTLPR) and the 521 C/T single nucleotide polymorphism (SNP) in the regulatory region of the dopamine D4 receptor gene (DRD4-521 C/T) were measured using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).ResultsAfter accounting for potential confounders, extroversion, psychopathy, neuroticism and time hurrying (impatience) were significant factors associated with road traffic accidents in bus drivers (adjusted OR: 1.268, 95% CI: 1.133–1.419; adjusted OR: 1.177, 95% CI: 1.028–1.347; adjusted OR: 1.092, 95% CI: 1.005–1.187; adjusted OR: 1.123, 95% CI: 1.025–1.230, respectively). Reduced serum levels of 5-HT and 5-HTP were significantly associated with the incidence of road traffic accidents (adjusted OR: 0.985, 95% CI: 0.973–0.997; adjusted OR: 0.982, 95% CI: 0.969–0.994, respectively).ConclusionsPsychological characteristics associated with the 5-HTTLPR and DRD4-521 C/T genotypes, including extroversion, psychopathy, neuroticism, and time hurrying (impatience), and low serum levels of 5-HT and 5-HTP in bus drivers were associated with an increased risk of road traffic accidents.