Vitiligo is an autoimmune skin disease characterized by presence of pale patchy areas of depigmentation. MicroRNAs (miRNAs) are important regulators of gene expression and play significant roles in diverse biological and pathological processes. Accumulating evidence has shown that miRNAs were differentially expressed in skin lesions and peripheral blood mononuclear cells of patients with vitiligo. In particular, miRNAs are significantly correlated with the development and progression of vitiligo. The abundance of some miRNAs in serum was also correlated with the vitiligo lesion severity, indicating that miRNAs might serve as prognostic biomarkers. Importantly, the direct involvement of miRNAs in the pathogenesis of vitiligo has been demonstrated. For example, increased expression of miR-25 contributes to vitiligo through promoting the dysfunction and oxidative stress-induced destruction of melanocytes. However, there are limited studies on the function and mechanism of deregulated miRNAs in vitiligo. Further studies are required to establish clinical applications of miRNAs for vitiligo. More in-depth investigations of miRNAs are needed for the understanding of the pathogenesis of vitiligo and the development of novel therapeutic targets. This present review summarizes the current literature on the deregulation and pathogenic roles of miRNAs in vitiligo. We also highlight the potential clinical applications of miRNAs in patients with vitiligo.

This study was developed to design a high-speed and high-power uni-traveling-carrier photodiode (UTC-PD). Gaussian doping is adopted in the absorption layer, and a thin-doped cliff layer is introduced above the collection layer. The effects on the high-speed performance of UTC-PD are analyzed, and the thickness and concentration of absorption layer, cliff layer, and collection layer are optimized. Then, the carrier optical detector is used in optical fiber communication system, and a small pluggable SFP fiber module is used to realize the conversion of photoelectric signal. Based on the test requirements, the test platform of optical fiber communication system is built, and the CPCI bus based on PCI9054 is designed to communicate with the industrial computer. Meanwhile, a multi-polarization and high-order modulation scheme is designed for optical signal. The effects of transmission power, transmission distance, and optical signal-to-noise ratio (OSNR) on the transmission performance of orthogonal amplitude modulation (DP-16QAM, DP-32QAM) signals are analyzed by simulation. Simulation analysis shows that the optimized UTC-PD has improved its high speed and saturation, whose 3 dB bandwidth is up to 56 GHz, and responsiveness up to 0.28 A/W. In high-speed serial differential data transmission, the optical fiber communication system based on carrier optical detector/CPCI bus receives and sends reliably, and the error code value is always 0. Based on the signal modulation scheme in this study, the increase of OSNR can reduce the bit error rate (BER), and the bit error rate of 2A8P-16QAM and 4A8P-32QAM will decrease, that is, the signal transmission needs a higher optical signal-to-noise ratio.

A method of removal of chloride in reinforced concrete was proposed by anodic oxidation of silver in the pore solution with chloride content over 0.4% by weight. The result shows that after anodic oxidation of silver plate the polarisation resistance of rebar will increase to the range of safety. The silver plate can be applied repeatedly.

No abstract