No abstract

jointly directed the study.

Background This study aimed to compare the effectiveness of endometrial receptivity analysis (ERA)-guided personalized embryo transfer (pET) with conventional frozen embryo transfer (FET) in 281 Chinese women with recurrent implantation failure (RIF). Material/Methods A total of 281 eligible patients with RIF were recruited and assigned to ERA (ERA followed by pET) and FET groups. The clinical pregnancy outcomes were compared between the 2 groups. Results There were no significant differences between the ERA and FET groups in terms of endometrial thickness on the day of embryo transfer, mean attempts of assisted reproductive technology (ART) treatment, anti-Mullerian hormone, follicle-stimulating hormone, or antral follicle count in the fresh cycle ( P >0.05). The ERA test identified 35% of samples as receptive and 65% as nonreceptive, and comparable pregnancy outcomes were observed between receptive and nonreceptive patients ( P >0.05). Higher pregnancy and implantation rates were found in the ERA group than in the FET group ( P <0.01), while no significant differences were detected between the 2 groups in terms of miscarriage rates ( P >0.05). Conclusions In this study of Chinese women with RIF undergoing in vitro fertilization and embryo transfer, ERA-guided pET resulted in a significant improvement in pregnancy and implantation rates when compared with FET.

Humidity sensing has a wide application and receives intense attention from a broad spectrum of research areas. In this work, we demonstrated a robust humidity sensing strategy by loading photoacid HPTS (8-hydroxypyrene-1,3,6-trisulfonic acid, trisodium salt) into nanopores of hollow mesoporous organosilica (HMO) capsules. Taking advantage of the capillary condensation of nanopores, water vapor is enriched, which triggers the fluorescent color change of HPTS through intermolecular excited-state proton transfer (ESPT) for humidity sensing. The ESPT induced fluorescent color change behavior of HPTS loaded in nanopores was comprehensively investigated by using both steady and picosecond time-resolved fluorescence spectroscopy. The fabricated humidity sensors exhibit rapid response and recovery, qualified reversibility, and selectivity, which enable continuous monitoring of human respiration. Notably, the sensing performance, i.e., sensitivity and response range, can be effectively tuned by fabricating HMO capsules with properly sized nanopores, which provides an opportunity to design unique nanostructures of the humidity sensor for specific applications.

As a common process in nature, excited-state proton transfer (ESPT) is becoming increasingly attractive due to its wide applications in smart sensors and materials. Compared with well-known ESPT in bulk solution, knowledge of ESPT between excited-state photoacids and silanols on mesostructured surfaces is still limited. Herein, we present our work on ESPT behavior in photoacid-embedded mesostructured CTAB−silica films by using steady and picosecond time-resolved fluorescence spectroscopy. Compared with ESPT in solutions, two unique characteristics of photoacid−silanol ESPT were revealed: (1) deprotonated silanols act as ESPT acceptors, while protonated silanols affect ESPT by changing the basicity of the silica surface; (2) largely distinguished properties of Q 3 /Q 2 silanols and their non-uniform distribution on the surface lead to heterogeneous properties of the surface such as basicity that greatly affect ESPT dynamics. Our work provides new insight into the ESPT mechanism in mesostructured systems and inspiration for designing smart sensors and materials that utilize the sensitivity to proton concentration.