Inspired by mussel-adhesion phenomena in nature, a simple, mild surface modification process was elaborated to endow the polyurethane (PU) substrate with antibacterial/antifouling properties. In the present study, polydopamine was coated directly onto polyurethane surfaces. AgNO was then added and absorbed onto the surface by the active catechol and amine groups of the polydopamine coating. Meanwhile, the adsorbed Ag ions were reduced in situ into metallic silver nanoparticles by the "bridge" of the polydopamine coating which yielded a coating with good antimicrobial properties. Finally, 1H, 1H, 2H, 2H-perfluorodecanethiol (CF (CF ) CH CH SH, F-SH) was attached on the PDA coating via the Michael addition reaction. The hydrophobic F-SH layer above the antibacterial layer yielded a surface with excellent antifouling properties. Preliminary antibacterial assays indicate that the coated surfaces show enhanced antibacterial activity against Escherichia coli (Gram-negative bacteria) and Staphylococcus aureus (Gram-positive bacteria). Platelet adhesion was significantly reduced for the F-SH-coated PU film. These results suggest that the modified PU could be used as an antibacterial material for future biomedical applications. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 531-538, 2017.

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Polyurethane micelles with disulfide bonds positioned mainly either at the hydrophobic PCL junctions (PU-SS-C) or at the connections between the hydrophilic PEG and hydrophobic PCL blocks (PU-SS-I) were developed as a antitumor drug carriers.

Biodegradable pH sensitive polyurethane micelles with a dense brush like coating of PEG were prepared. The PTX-loaded PEG-g-PU-3 micelles exhibited potent cytotoxicity against H460 cancer cells compared to PEG-b-PU-3 and PEG-c-PU-3 micelles.