Background: Lithocarpus bancanus or commonly called as mempening in Talang Mamak Tribe, Indonesia is a plant that is used as a traditional medicine. Objective: This study aim to evaluated antioxidant and antidiabetic activities of L. bancanus leaves extract. Material and Methods: The methanol extract was obtained by maceration of the leaves. The n-hexane, dichloromethane and ethyl acetate fractions were prepared by successive partition process of the methanol extract. Antioxidant activities were evaluated by various antioxidant assays, including DPPH (1,1-diphenyl-2-picrylhydrazyl), FRAP (ferric reducing antioxidant power), CUPRAC (cupric reducing antioxidant capacity), and ABTS (2,2'-azonobis 3-ethylbenzothiazoline-6-sulfonic acid) method. Total phenolics were estimated based on the Folin-Ciocalteu method, while, aluminum chloride methods were employed to estimate total flavonoids. Antidiabetic activies was determined by inhibiting the activity of α-glucosidase method. Results: antioxidant activity assay against DPPH radical as well as the total phenolic and flavonoid content of L. bancanus leaves showed that the methanol extract possessed IC 50 value of 39.469 ± 0.273 μg/mL with total phenol and flavonoid were 11.426 ± 0.432 mg GAE/g dry weight sample and 15.423 ± 0.213 mg QE/g respectively. The FRAP, CUPRAC and ABTS values of methanol extract were 3494.302 ±0.456 , 26665.501 ± 5.940 and 2857.977 ± 0.715 μM TE/g dry weight sample respectively. Antidiabetic activity of methanol extract with IC 50 value of 30.565 ± 0.331 µg/mL. Conclusion: It could be concluded that leaves of L. bancanus have antioxidant and antidiabetic properties.

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Abstract:The title compound, 3,5-bis(2-hydroxybenzylidene)piperidin-4-one (3), was prepared via reaction of 2-hydroxybenzaldehyde (1) and 4-piperidone (2) under microwave irradiation in the presence of 10% NaOH solution. The compound was fully characterized from its UV, IR, NMR and MS data. Keywords: curcuminoids; aldol condensation; 4-piperidoneCurcumin is ubiquitous in many Curcuma species and is the major pigment found in the tumeric plant, Curcuma longa. Chemically, curcumin is a phenolic secondary metabolite known to possess anti-inflammatory [1], antioxidant [2], antiviral, anti-infective and anti-allergic activity [4], as well as anti-HIV [5] and anti-cancer [6] properties. Based on the wide range of its biological activities, curcumin has attracted much interst as a model for new target compounds to be synthesized. However, the isolation of curcuminoids from natural substances is low-yielding (3%-5% of the dry-weight), and in addition, the curcuminoids thus obtained possess limited structural variability. Indeed, this method presents an obstacle to optimize the function of curcumin [7]. Therefore, synthesis of curcumin OPEN ACCESS