We report the design and synthesis of a new class of fluorogenic probes based on monoamine oxidase-triggered oxidative C-O bond cleavage. The selectivity of probe P1 towards MAO-B was 22-fold higher than that towards MAO-A.

We report the design and synthesis of a new class of fluorogenic probes based on a monoamine oxidase-B (MAO-B)-catalyzed a-carbon oxidation-hydrolysis mechanism. The cell-permeable probes exhibited good selectivity and sensitivity towards MAO-B, and a turn-on response in fluorescence intensity in living cells.