Author's summary We demonstrated that the electrical remodeling represented by low voltage zone is a better marker for the prediction of recurrence after radiofrequency catheter ablation as compared with structural remodeling measured by left atrium (LA) diameter. The study provides important clue that further deep dive into LA substrate research will be important to improve success rate of non-paroxysmal atrial fibrillation ablation.

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Author's summary Inherited arrhythmia is a more common cause of sudden cardiac arrest in Asian population, yet less is known of genetic background compared to western population. Certain clinical differences were found in the three most common disease: idiopathic ventricular fibrillation (IVF), Brugada syndrome (BrS), and long QT syndrome (LQTS). Patients detected with certain genotype resulted lower left ventricular ejection fraction compared to those without detected genotype (54.7±11.3 vs. 59.3±9.2%, p=0.005). Genetic yield was relatively low in BrS (19.5%) and LQTS (23.5%), whereas IVF revealed higher genetic yield (54.0%), suggesting its susceptibility to concealed cardiomyopathy.

On the cover: The cover image is based on the Original Article Characteristics of atrial fibrillation patients suffering atrioesophageal fistula after radiofrequency catheter ablation, by Yun Gi Kim et al., DOI: https://doi.org/10.1111/jce.13671.

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