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A novel bilayer chitosan membrane was prepared by a combined wet/dry phase inversion method and evaluated as a wound dressing. This new type of bilayer chitosan wound dressing, consisting of a dense upper layer (skin layer) and a sponge-like lower layer (sublayer), is very suitable for use as a topical delivery of silver sulfadiazine (AgSD) for the control of wound infections. Physical characterization of the bilayer wound dressing showed that it has excellent oxygen permeability, that it controls the water vapor transmission rate, and that it promotes water uptake capability. AgSD dissolved from bilayer chitosan dressings to release silver and sulfadiazine. The release of sulfadiazine from the bilayer chitosan dressing displayed a burst release on the first day and then tapered off to a much slower release. However, the release of silver from the bilayer chitosan dressing displayed a slow release profile with a sustained increase of silver concentration. The cultures of Pseudomonas aeruginosa and Staphylococcus aureus in agar plates showed effective antimicrobial activity for 1 week. In vivo antibacterial tests confirmed that this wound dressing is effective for long-term inhibition of the growth of Pseudomonas aeruginosa and Staphylococcus aureus at an infected wound site. The results in this study indicate that the AgSD-incorporated bilayer chitosan wound dressing may be a material with potential antibacterial capability for the treatment of infected wounds.

S U M M A R YTaiwan Chelungpu-fault Drilling Project (TCDP) was initiated to understand the physical mechanisms involved in the large displacements of the 1999 Taiwan Chi-Chi earthquake. Continuous measurements of cores (including laboratory work) and a suite of geophysical downhole logs, including P-and S-wave sonic velocity, gamma ray, electrical resistivity, density, temperature, electrical borehole images and dipole-shear sonic imager, were acquired in Hole-A over the depth of 500-2003 m. Integrated studies of cores and logs facilitate qualitative and quantitative comparison of subsurface structures and physical properties of rocks. A total of 10 subunits were divided on the basis of geophysical characteristics. Generally, formation velocity and temperature increase with depth as a result of the overburden and thermal gradient, respectively. Gamma ray, resistivity, formation density, shear velocity anisotropy and density-derived porosity are primarily dependent on the lithology. Zones with changes of percentage of shear wave anisotropy and the fast shear polarization azimuth deduced from Dipole Shear-Imager (DSI) are associated with the appearance of fractures, steep bedding and shear zones. The fast shear wave azimuth is in good agreement with overall dip of the bedding (approximately 30 • towards SE) and maximum horizontal compressional direction, particularly in the Kueichulin Formation showing strong shear wave velocity anisotropy. Bedding-parallel fractures are prevalent within cores, whereas minor sets of high-angle, NNW-SSE trending with N-and S-dipping fractures are sporadically distributed. The fault zone at depth 1111 m (FZA1111) is the Chi-Chi earthquake slip zone and could be a fluid conduit after the earthquake. The drastic change in fast shear wave polarization direction across the underlying, non-active Sanyi thrust at depth 1710 m reflects changes in stratigraphy, physical properties and structural geometry.

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