Hypopharyngeal squamous cell carcinoma (HPSCC) accounts for approximately 3% of all head and neck squamous cell carcinoma (HNSCC). The incidence of HPSCC has increased during the past three decades. 1,2 Although HPSCC is relatively uncommon, it is one of aggressive and lethal forms among HNSCCs. HPSCC is characterized by its wide submucosal spread, early lymph node metastasis, distal metastasis and diagnosis with a later stage. Although improvements have been made to treatments, such as surgery, radiotherapy, chemotherapy, immunotherapy and in their combination in recent decades, 3,4 the 5 years overall survival of HPSCC remains approximately 30%-35%. 5 As hypopharynx is anatomically adjacent to the larynx, the advancedstage HPSCC may severely impair the structure and function of the