Wearable contact lenses which can monitor physiological parameters have attracted substantial interests due to the capability of direct detection of biomarkers contained in body fluids. However, previously reported contact lens sensors can only monitor a single analyte at a time. Furthermore, such ocular contact lenses generally obstruct the field of vision of the subject. Here, we developed a multifunctional contact lens sensor that alleviates some of these limitations since it was developed on an actual ocular contact lens. It was also designed to monitor glucose within tears, as well as intraocular pressure using the resistance and capacitance of the electronic device. Furthermore, in-vivo and in-vitro tests using a live rabbit and bovine eyeball demonstrated its reliable operation. Our developed contact lens sensor can measure the glucose level in tear fluid and intraocular pressure simultaneously but yet independently based on different electrical responses.

This study presents a soft, smart contact lens that provides real-time sensing for diabetes through a wireless display.

Three different treatment protocols (oral steroid, ITDI, or the combination) resulted in similar hearing recovery rates. Therefore, OPD-based systemic and/or local steroid therapy can be recommended as an initial treatment in ISSNHL.

To analyze the effects of strain rate and viscoplastic strain on consolidation of natural clay, this paper presents a nonlinear viscoplastic model in which viscoplastic behaviour is modeled by a unique effective stress ( σ v ′ ) -viscous strain (ε v ) -viscous strain rate ( & ε v ) relationship. The proposed model can consider the effects of strain rate and viscoplastic strain on consolidation, to take into account the difference in strain rate between laboratory and field conditions, and the combined processes of generation and dissipation of pore pressure during consolidation. This model can also predict the behaviour of clay during stepwise loading, constant rate of strain, and relaxation of effective stress. The predicted values using numerical analysis are compared with measured values in laboratory tests and in situ, under an embankment built on soft clay at Berthierville, Quebec. It is possible to estimate the consolidation behaviour of natural clay with reasonable accuracy using the proposed nonlinear viscoplastic model.Résumé : Dans le but d'analyser les effets de la vitesse de déformation et de la déformation viscoplastique sur la consolidation de l'argile naturelle, cet article présente un modèle viscoplastique non linéaire dans lequel le comportement est modélisé par une relation unique contrainte effective-déformation visqueuse-vitesse de déformation visqueuseLe modèle proposé peut prendre en considération les effets de la vitesse de déformation et de la déformation viscoplastique sur la consolidation pour tenir compte de la différence dans les vitesses de déformation entre les conditions en laboratoire et sur le chantier, de même que les processus combinés de génération et de dissipation de la pression interstitielle durant la consolidation. Ce modèle peut aussi prédire le comportement de l'argile en incluant le chargement par étape, la vitesse de déformation constante, et la relaxation de la contrainte effective. Les valeurs prédites au moyen de l'analyse numérique sont comparées avec celles mesurées dans les essais en laboratoire et in situ sous un remblai construit sur de l'argile molle à Berthierville, Québec. Il est possible d'estimer le comportement en consolidation de l'argile naturelle avec une précision raisonnable au moyen du modèle viscoplastique non linéaire proposé.

C-H activation is a versatile tool for appending aryl groups to aromatic systems. However, heavy demands on multiple catalytic cycle operations and site-selectivity have limited its use for graphene segment synthesis. A Pd-catal- yzed one-step synthesis of functionalized triphenylene frameworks is disclosed, which proceeds by 2- or 4-fold C-H arylation of unactivated benzene derivatives. A Pd (dibenzylideneacetone) catalytic system, using cyclic diaryliodonium salts as π-extending agents, leads to site-selective inter- and intramolecular tandem arylation sequences. Moreover, N-substituted triphenylenes are applied to a field-effect transistor sensor for rapid, sensitive, and reversible alcohol vapor detection.