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The present study was aimed at investigating whether an altered role of nitric oxide (NO) is involved in chronic renal failure (CRF). Rats were subjected to 5/6 nephrectomy and kept for 6 weeks to induce CRF. On the experimental day, after measurement of arterial pressure under anesthesia, the arterial blood was collected, and thoracic aorta and kidney were rapidly taken. NO metabolites (NOx) were determined in the plasma, urine, aorta and kidney. The expression of NO synthase (NOS) isozymes was determined in the kidney and aorta by Western blot analysis. The expression of NOS mRNA in the glomeruli was also determined by RT-PCR. There were significant increases in arterial pressure and serum creatinine levels in CRF. Urine NOx levels were decreased in CRF, whereas plasma NOx levels were not altered. Aorta and kidney tissue NOx levels were also decreased in CRF. The expression of endothelial constitutive (ec) and inducible (i) isoforms of NOS proteins was decreased in the kidney and aorta in CRF. Accordingly, the expression of ecNOS and iNOS mRNA was decreased in the glomeruli in CRF. In conclusion, NO synthesis is decreased in the kidney and vasculature of CRF rats.

Purpose: This research was implemented for men in their thirties who have lower back pain to observe general activity disorder patterns during pinch lift and rubbing manual therapy (PMT) and stretching application. Methods: Participants were divided into three groups: The PMT Group used applied pinch lift and rubbing manual therapy; the STR Group used applied stretching; and the CON Group was the control group. Participants for each group received treatments that were conducted three times a week for a total five weeks. Measures of pain utilized Visual Analogue Scale (VAS) [INCOMPLETE SENTENCE]. Results: There were significant differences between the PMT Group and the CON Group as well as the STR Group and the CON Group for pain, muscle strength and flexibility. There was a significant difference in pain between the PMT Group and the STR Group. Conclusion: As a result, it is inferred that PMT and stretching positively influenced recovery with regards to pain, muscle strength and flexibility relief; however PMT is more effective for pain relief than stretching.