Herein, we report a Rh(III)‐catalyzed 1,3‐dienylation of isoquinolin‐1(2H)‐ones through C−H activation. The present reaction enables the preparation of 3‐(buta‐1,3‐dien‐2‐yl)isoquinolin‐1(2H)‐ones through the direct cross‐coupling reaction of readily available isoquinolin‐1(2H)‐ones with methylenecyclopropanes, while tolerating many sensitive functional groups. Therefore, this method provides an efficient and convenient approach for modification of interesting molecules.magnified image

A set of poly(L-lactide)-poly(e-caprolactone) diblock copolymers (AB) and poly(L-lactide)-poly(e-caprolactone)-poly(L-lactide) triblock copolymers (ABA) with predictable molecular weights and relatively narrow distributions were synthesized by ring-opening polymerization of successively added e-caprolactone (e-CL) and L-lactide (LLA) using 4-methyl benzo-12-crown-4 imidazol-2-ylidene as catalyst. The effects of polymerization conditions, such as reaction time, temperature, monomer/catalyst molar ratio and monomer concentration on the copolymerization have been discussed in detail. The resulting copolymers were characterized by 1 H-NMR, 13 C-NMR, IR, GPC and DSC methods which confirmed the successful synthesis of block copolymers of LLA and e-CL. Hydrolytic degradation of the polymers showed that the PLLA-PCL-PLLA copolymer exhibited faster degradation as compared with the PCL homopolymer in alkaline medium at 37 C.

A new and facile AgSbF-mediated protocol for the construction of C-4 thiolated or selenylated isoquinolin-1(2 H)-ones via a radical pathway was established. This reaction proceeded efficiently with excellent regioselectivity, a broad substrate scope, and good functional group tolerance. A radical reaction mechanism involving thiyl radicals as key intermediates is proposed for the present transformation.

Under rhodium(III) catalysis, substituted N‐methoxycycloalkene‐1‐carboxamides successfully reacted with aryl boronic acid pinacol esters to provide 3,4‐cycloalkaquinolin‐2(1H)‐ones via direct functionalization of the β‐alkenyl C−H bond and form C−C/C−N bond in one pot. The gram‐scale synthesis of the title compound demonstrated the great synthetic utility of this methodology.magnified image

A microwave‐assisted method for the synthesis of 8‐methylquinoline derivatives via Rh‐catalyzed C(sp3)‐H activation under solvent‐free condition is reported. In comparison with traditional method, this reaction proceeded more efficiently with excellent yield, a broad range substrate scope and good functional group tolerance.