Background: Diabetes mellitus (DM) and its complications pose serious threats to global public health. As diabetes is a systemic metabolic disease, various studies have shown that it is associated with oxidative stress. Therefore, studies linking diabetes and oxidative stress have received considerable attention. However, no previous studies have analysed the relationship between diabetes and oxidative stress through a bibliometric approach. To fill this knowledge gap and summarise the research hotspots and trends, we conducted a comprehensive bibliometric analysis of global scientific publications in this field. Methods: We extracted all relevant English-language publications on diabetes and oxidative stress from the Web of Science between 1 January 2003 and 31 October 2022. CiteSpace V 5.8.R3, VOSviewer 1.6.16, and two online analysis platforms were used for bibliometric and visual analyses. Results: A total of 44291 articles were identified, including 33,710 articles, 9473 reviews, and 1108 meeting abstracts. The number of publications has increased gradually over the past 20 years. China and the United States are the largest contributors to publications in this field. China Med University is the institution with most publications, and LU CAI is the author with the most publications. There is relatively little collaboration among institutions in different countries. The journal that published the most papers related to diabetes and oxidative stress is the International Journal of Molecular Sciences. According to co-cited references result, ‘bioactive compounds’, ‘SGLT2 inhibitors’, ‘diabetic cardiomyopathy’, and ‘diabetic retinopathy’ are the main research hotspots. Based on the results of the topic evolution, ‘risk’, ‘expression’, ‘oxidative stress’, and ‘antioxidant activity’ are focal points of current research. Conclusion: This study provides a systematic and objective view of the field, which helps readers evaluate the characteristics of publications involving diabetes and oxidative stress and helps researchers formulate rational research protocols.

Objective/Background: Cancer is one of the leading causes of death in the world. Therefore, there is an urgent need to develop new drugs for fighting this disease. Recent studies have reported that antimicrobial peptides (AMPs) can be used as anticancer drugs. Methods: We discovered brevinin-1EG, a novel antimicrobial peptide from Pelophylax nigromaculatus, using gene cloning techniques. Brevinin-1EG was then investigated for its structure and biological activity. Results: Brevinin-1EG, with an alpha-helical structure, showed broad-spectrum anti-proliferative activity against several cancer cell lines, including U-2OS, HepG2, HT-29, A375, HeLa, and A549 cells, with IC50 values ranging from 15 to 22 μg/mL. These same concentrations were insufficient to induce hemolysis in erythrocytes, indicating the safety of this molecule. Brevinin-1EG also exhibited antioxidant activity, scavenging ABTS·+ and DPPH free radicals. Conclusion: Brevinin-1EG has good safety and potential use as an anticancer therapeutic agent. It provides support for the research of new peptide drugs and templates for structural modification.