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Aim The aim of this study was to explore the experience and perceptions of patients with Crohn’s disease in China. Methods Data mining was used to investigate posts in Crohn’s disease online medical communities. The data were collected through the crawler code, and latent Dirichlet allocation (LDA) and grounded theory were used to mine the theme features after data cleaning. Results In analyzing the topic characteristics of online posts, LDA divided 6757 posts into 15 topics on four aspects: seeking disease information, making decisions on medication use, psychological burden, and communicating about diet and nutrition. Conclusion Overall, social media is patient-centric and helps us better understand the experiences and perceptions of patients. This study can help medical staff predict the thoughts and concerns of Crohn's disease patients during the treatment process, facilitate doctor-patient communication, and assist in the formulation of medical policies.

Background：Inflammatory bowel disease (IBD) is an idiopathic intestinal inflammatory disease involving ileum, rectum and colon, including ulcerative colitis (UC) and Crohn's disease (CD).The etiology is complex, and immune dysfunction is considered to be the final pathological result. Methods：We constructed a lncRNA-mRNA regulatory network based on ferroptosis-related and immnue-related differentially expressed lncRNAs in IBD. Results: We identified 6 differently expressed lncRNAs associated with of ferroptosis and immune in IBD. We further constructed lncRNA-mRNA regulatory network and found potential miRNAs and transcription factors (TF) based on trans and ceRNAs mechanisms.Conclusion：Ferroptosis and immune related lncRNA participate in the regulation of abnormal immune response in IBD