Abstract. Purpose :To compare various recovery quality of sevoflurane and desflurane in elderly patients underwent thoracoscopic lobectomy, and to provide a reliable basis for anesthesiologists to choose anesthesia maintaining drugs.Method :Sixty elderly patients undergoing thoracoscopic lobectomy were selected from October, 2015 to May, 2016, and were divided into two groups by random number table, namely, the group of Dofetilide (group D) 30 cases, and sevoflurane (group S) 30 cases.The time of spontaneous respiration, the time of eye opening, the time of extubation and the time of awakening were recorded respectively in two groups. The incidence of nausea, vomiting and restlessness were also recorded.Result:There is no statistical difference comparing data of two groups.The time of spontaneous respiration, the duration of spontaneous breathing, the time of conscious recovery, the time of extubation and the time of leaving the room were shorter in group D than in group S, the difference was statistically significant (P <0.05). (3) There were no significant differences in the incidence of adverse events between the two groups (P> 0.05).Conclusion :Compared with sevoflurane, desflurane can reduce the extubation and awakening time, improve the quality of awakening and speed up the turnover of surgery, and it has certain clinical application advantage for thoracoscopic lobectomy in elderly patients.

This study investigated the protective effect of desoxyrhapontigenin (DOP) against isoflurane (ISF)-induced neuronal injury in rats. Neuronal injury was induced in pups by exposing them to 0.75% ISF on postnatal day 7 with 30% oxygen for 6 h. The pups were treated with DOP 10 mg/kg, i.p., for 21 days after ISF exposure. The protective effect of DOP was estimated by assessing cognitive function using the neurological score and the Morris water maze. Neuronal apoptosis was assessed in the hippocampus using the TUNEL assay, and protein expression of caspase-3, Bax, and Bcl-2 was measured by Western blotting. The levels of cytokines and oxidative stress parameters were assessed by ELISA. Western blotting and RT-PCR were performed to measure the expression of NF-kB, TLR-4, Sirt-1, and cyclin B1 protein in the brain. The cognitive function and neurological function scores were improved in the DOP group compared with the ISF group. Moreover, DOP treatment reduced the number of TUNEL-positive cells and the expression of caspase-3, Bax, and Bcl-2 protein in the brains of rats with neuronal injury. The levels of mediators of inflammation and oxidative stress were reduced in the brain tissue of the DOP group. Treatment with DOP attenuated the protein expression of TLR-4, NF-kB, cyclin B1, and Sirt-1 in the brain tissue of rats with neuronal injury. In conclusion, DOP ameliorates neuronal apoptosis and improves cognitive function in rats with ISF-induced neuronal injury. Moreover, DOP treatment can prevent neuronal injury by regulating the TLR-4/cyclin B1/Sirt-1 pathway.

Purpose:To analysis clinical experience of applying recurrent laryngeal monitoring endotracheal tube (NIM EMG Endotracheal Tube) in the surgery of thyroid.Method:A retrospective analysis of 84 patients who underwent endotracheal intubation laryngeal nerve monitoring by thyroid surgery in the Chinese-Japanese Friendship Hospital of Jilin University from March to December in 2015.To summarize the experience of intubation with NIM EMG Endotracheal Tube.Result 77 (91.7%)had initial intubation achievement in the 84 patients.FROM the 77 cases we had gotten s atisfactory nerve monitoring signal.Whereas there are 7 cases (8.3%) appear abnormal EMG or signal missing,in the 7 cases there is one which being intubated too deep ,3 cases which being intubated too shallow and 3 cases with malrotation intubation.Conclusion:We got the satisfactory signals after adjust 1 ing the tube by using the visual laryngoscope.