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In response to prepare high-stable and ion-conducting polyelectrolyte for hydroxide exchange membrane (HEM) applications, we present an ultrastable polyelectrolyte based on six-membered heterocyclic 6-azonia-spiro[5.5]undecane (ASU) and polyphenyl ether (PPO). A series of ASU-functionalized PPO polyelectrolytes (ASU-PPO), which can be easily dissolved in low-boiling pointing solvent, have been successfully synthesized by a remote-grafting method. The ASU precursor is stable in 1 M NaOH/DO at 80 °C for 2500 h as well as in 5 M NaOH/DO at 80 °C for 2000 h, and the predicted half-life of the ASU precursor would exceed 10 000 h, even higher in the future. Besides, these remote-grafting ASU-PPO polyelectrolytes are stable in 1 M NaOH at 80 °C for 1500 h. Robust and pellucid segmented ASU and triple-ammonium-functionalized PPO-based HEMs attach OH conductivity of 96 mS/cm at 80 °C and realize maximal power density of 178 mW/cm under current density of 401 mA/cm.

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The Krüppel-like factor 5 (KLF5) transcription factor is highly expressed in basal type breast cancer and promotes breast cancer cell proliferation, survival, migration, and tumorigenesis. KLF5 protein stability is regulated by ubiquitination. In this study, ubiquitin-specific protease 3 (USP3) was identified as a new KLF5 deubiquitinase by genome-wide siRNA library screening. We demonstrated that USP3 interacts with KLF5 and stabilizes KLF5 via deubiquitination. USP3 knockdown inhibits breast cancer cell proliferation in vitro and tumorigenesis in vivo, which can be partially rescued by ectopic expression of KLF5. Furthermore, we observed a positive correlation between USP3 and KLF5 protein expression levels in human breast cancer samples. These findings suggest that USP3 is a new KLF5 deubiquitinase and that USP3 may represent a potential therapeutic target for breast cancer.

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