Due to the lack of an effective method for the treatment of fibrosis, there are numerous patients suffering from the effects of fibrosis. Severe fibrosis can cause dysfunction of relevant organs characterized by excessive deposition of extracellular matrix components. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a long non-coding RNA that is widely expressed and highly conserved in human tissues. It can regulate gene expression at various molecular levels, involved in the fibrosis of the liver, heart, lung, and kidney. In this review, we first described the pathogenesis by which MALAT1 promotes fibrosis. Furthermore, we summarized current studies of MALAT1 in the fibrosis of various organs. Hope this review will contribute to a better understanding of the molecular mechanism of fibrosis and the potential of MALAT1 as a novel therapeutic target for fibrosis.

Background. At present, with the continuous development of nanotechnology, great changes have taken place in people’s lives in medical treatment, production, daily leisure, and so on. Nanooptical technology is entirely based on nanotechnology that laser and visible light are limited to submicron structures (nanopores, nanoslits, and nanoneedles). Due to the great development potential of nanooptical technology in nanoscale sensors, TOF camera applications, THz imaging technology, and other imaging equipment materials and applications, people have been interested in it, recently. Scope and Approach. In this review, the importance of good practices for nanooptical technology used in equipment as both nanometer scale sensors and optical auxiliary equipment is described. Based on recent reports, this work discussed the development of nanooptical technology in daily photography and medical imaging from both the positive and the negative sides and compared the engineering techniques. Key Findings and Conclusions. As a kind of new optical technology, nanooptical technology can produce the plasmonic effect under the intense collision of atoms and electrons in nanostructures. It has significant effects in superresolution nanolithography, high-density data storage, near-field optics, and other fields. Although the current nanooptic technology is not extremely mature, the results obtained from current works are pointing out that nanooptical technology is the future of daily imaging and medical imaging, and it also will play a positive role in the improvement of people’s health and ecological environment quality. As a trend, nanooptical technology is developing in the direction of energy-saving, portability, high efficiency, and low pollution, and in the upsurge of environmental protection in the world, nanooptical technology will surely achieve amazing development in the field of daily photography and medical imaging. Under the huge market demand and innovation power, nanophotonics technology will cover all emerging technologies that share the same research field with it and take advantage of each technology (terahertz, cell and molecular microscopy, and nanoscale probes) to develop an unprecedented new century in nanoscience. The future trends of research contain finding new imaging equipment with nanostructure, designing nanooptical products, and improving engineering techniques.