A concise and practical method for the metal‐free synthesis of 1,8‐naphthyridones is described using a two‐step approach involving regioselective amination of pyridine N‐oxides and acid‐mediated cyclization. This is the first synthesis of 1,8‐naphthyridones utilizing easily accessible pyridine N‐oxides as substrates. Compared to previous reports, this method benefits from simple operation, easy access to starting materials, and a wide substrate scope, providing a variety of novel 1,8‐naphthyridones.
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